Zinc Finger Protein RFP (TRIM27) Antibody – Rabbit Polyclonal

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008]

TRIM27: Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspase-3-like activity independently of mitochondrial events. May function in male germ cell development. Has DNA-binding activity and preferentially bound to double-stranded DNA. E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of 'Lys-48'-linked polyubiquitin chains; the function inhibits CD4 T-cell activation. Defects in TRIM27 are a cause of thyroid papillary carcinoma (TPC). TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. A chromosomal aberration involving TRIM27/RFP is found in thyroid papillary carcinomas. Translocation t(6;10)(p21.3;q11.2) with RET. The translocation generates TRIM27/RET and delta TRIM27/RET oncogenes. Belongs to the TRIM/RBCC family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; Motility/polarity/chemotaxis; EC 6.3.2.-; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 6p22

Cellular Component: cytoplasm; early endosome; endosome; integral to plasma membrane; membrane; nuclear membrane; nucleoplasm; nucleus; PML body; retromer complex

Molecular Function: DNA binding; ligase activity; metal ion binding; nucleic acid binding; protein binding; transmembrane receptor protein tyrosine kinase activity; ubiquitin-protein ligase activity; zinc ion binding

Biological Process: cell proliferation; innate immune response; negative regulation of adaptive immune response; negative regulation of gene expression, epigenetic; negative regulation of protein kinase activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of tumor necrosis factor production; negative regulation of viral transcription; peptidyl-tyrosine phosphorylation; positive regulation of actin nucleation; positive regulation of transcription factor activity; retrograde transport, endosome to Golgi; spermatogenesis; transcription, DNA-dependent