GPRC5A Antibody – Rabbit Polyclonal

This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation. [provided by RefSeq, Jul 2008]

RAIG1: a G protein coupled receptor that is induced by all-trans retinoic acid (ATRA). Retinoic acids (RA) are a group of pleiotropic signaling molecules that regulate a broad range of physiologic and developmental processes. RAIG1 is expressed in lung tissue and in several lung cancer cell lines. This retinoic acid-inducible GPCR provides evidence for an interaction between retinoid and G-protein signaling pathways.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 3; Receptor, GPCR

Chromosomal Location of Human Ortholog: 12p13.1

Cellular Component: cytoplasmic vesicle membrane; integral to plasma membrane; intracellular membrane-bound organelle; plasma membrane

Molecular Function: G-protein coupled receptor activity; protein binding

Biological Process: G-protein coupled receptor protein signaling pathway; negative regulation of epidermal growth factor receptor activity; signal transduction