CYP4F12 Antibody – Rabbit Polyclonal

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein likely localizes to the endoplasmic reticulum. When expressed in yeast the enzyme is capable of oxdizing arachidonic acid. It can also catalyze the epoxidation of 22:6n-3 and 22:5n-3 polyunsaturated long-chain fatty acids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

CYP4F12: Catalyzes leukotriene B4 omega-hydroxylation and arachidonic acid omega-hydroxylation but with an activity much lower than that of CYP4F2. Catalyzes the hydroxylation of the antihistamine ebastine. Belongs to the cytochrome P450 family.

Protein type: Membrane protein, integral; EC 1.14.13.30; Membrane protein, multi-pass; Oxidoreductase

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: apical plasma membrane; cytoplasm; endoplasmic reticulum membrane; integral to membrane; intracellular membrane-bound organelle

Molecular Function: alkane 1-monooxygenase activity; arachidonic acid epoxygenase activity; heme binding; iron ion binding; leukotriene-B4 20-monooxygenase activity

Biological Process: arachidonic acid metabolic process; drug metabolic process; epoxygenase P450 pathway; long-chain fatty acid metabolic process; pressure natriuresis; renal water homeostasis; sodium ion homeostasis; very-long-chain fatty acid metabolic process; vitamin E metabolic process; xenobiotic metabolic process