OGG1 Antibody – Rabbit Polyclonal

This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008]

OGG1: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta- lyase activity that nicks DNA 3' to the lesion. Defects in OGG1 may be a cause of renal cell carcinoma (RCC). It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma. Belongs to the type-1 OGG1 family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA repair, damage; Deoxyribonuclease; EC 4.2.99.18; Lyase

Chromosomal Location of Human Ortholog: 3p26.2

Cellular Component: mitochondrion; nuclear matrix; nuclear speck; nucleoplasm; nucleus; protein complex

Molecular Function: 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity; damaged DNA binding; endonuclease activity; microtubule binding; oxidized purine base lesion DNA N-glycosylase activity; oxidized purine DNA binding; protein binding

Biological Process: acute inflammatory response; aging; base-excision repair; base-excision repair, AP site formation; depurination; depyrimidination; DNA repair; negative regulation of apoptosis; nucleotide-excision repair, DNA incision; regulation of protein import into nucleus, translocation; regulation of transcription, DNA-dependent; response to DNA damage stimulus; response to drug; response to estradiol stimulus; response to ethanol; response to folic acid; response to light stimulus; response to oxidative stress; response to radiation

Disease: Renal Cell Carcinoma, Nonpapillary