ZBTB18 Antibody – Rabbit Polyclonal

This gene encodes a C2H2-type zinc finger protein which acts a transcriptional repressor of genes involved in neuronal development. The encoded protein recognizes a specific sequence motif and recruits components of chromatin to target genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

ZNF238: Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'- [AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; Transcription factor

Chromosomal Location of Human Ortholog: 1q44

Cellular Component: intercellular bridge; microtubule cytoskeleton; nuclear chromosome; nucleoplasm; nucleus

Molecular Function: DNA binding; metal ion binding; protein binding; sequence-specific DNA binding; transcription factor activity

Biological Process: cerebellum development; cerebral cortex development; hippocampus development; homeostasis of number of cells; in utero embryonic development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; neuron development; regulation of cell division; skeletal muscle development; transcription, DNA-dependent

Disease: Mental Retardation, Autosomal Dominant 22