Serine Hydroxymethyltransferase (SHMT1) Antibody – Rabbit Polyclonal

This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

SHMT1: Interconversion of serine and glycine. Belongs to the SHMT family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - glycine, serine and threonine; EC 2.1.2.1; Cofactor and Vitamin Metabolism - one carbon pool by folate; Other Amino Acids Metabolism - cyanoamino acid; Energy Metabolism - methane; Mitochondrial; Methyltransferase; Lyase

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: cytoplasm; cytosol; mitochondrion; nucleus

Molecular Function: glycine hydroxymethyltransferase activity; L-allo-threonine aldolase activity; protein binding; protein homodimerization activity; pyridoxal phosphate binding

Biological Process: branched chain family amino acid catabolic process; carnitine biosynthetic process; dTMP biosynthetic process; folic acid metabolic process; glycine biosynthetic process from serine; glycine metabolic process; L-serine catabolic process; L-serine metabolic process; protein homotetramerization; protein tetramerization; purine base biosynthetic process; tetrahydrofolate metabolic process; vitamin metabolic process; water-soluble vitamin metabolic process