Rabbit Anti-AGXT Polyclonal Antibody – Cat# MBS1493048

Serine-Pyruvate Aminotransferase (AGXT) Antibody – Rabbit Polyclonal

Name: AGXT Antibody; Polyclonal; Rabbit; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS1493048
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1493048

Dual metabolic roles of gluconeogenesis (in the mitochondria) and glyoxylate detoxification (in the peroxisomes). More details

$230 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Serine-pyruvate aminotransferase (Agxt), Polyclonal Antibody

Full Product Name

Rabbit anti-mouse Serine-pyruvate aminotransferase, mitochondrial polyclonal Antibody(Agxt), HRP conjugated

Product Gene Name

anti-Agxt antibody

Product Synonym Names

SPT; AGT; Agxt1; Agxt

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Mouse

Purity/Purification

Caprylic Acid Ammonium Sulfate Precipitation Purified

Preparation and Storage

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Matching Pairs

Unconjugated Antibody: Agxt (MBS1496909)
HRP Conjugated Antibody: Agxt (MBS1493048)

Molecular Weight

43,520 Da

3D Structure

ModBase 3D Structure for O35423

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Conjugate

HRP

Immunogen

Recombinant mouse Serine--pyruvate aminotransferase, mitochondrial protein(25-414AA)

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-Agxt antibody

ELISA (EIA)

Other Notes

Small volumes of anti-Agxt antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Agxt purchase

MBS1493048 is an antibody targeting Agxt. Also known as Rabbit anti-mouse Serine-pyruvate aminotransferase, mitochondrial polyclonal Antibody(Agxt), HRP conjugated. Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Agxt. It may not necessarily be applicable to this product.

NCBI GI #

111038130

NCBI GeneID

11611

NCBI Accession #

NP_057911.2

UniProt Primary Accession #

O35423

UniProt Secondary Accession #

Q8R128

UniProt Related Accession #

O35423

GenBank Nucleotide #

NM_016702.3

NCBI Official Full Name

serine--pyruvate aminotransferase, mitochondrial isoform 1

NCBI Official Synonym Full Names

alanine-glyoxylate aminotransferase

NCBI Official Symbol

Agxt

NCBI Official Synonym Symbols

AGT; SPT; Agt1; Agxt1

UniProt Protein Name

Serine--pyruvate aminotransferase, mitochondrial

UniProt Synonym Protein Names

Alanine--glyoxylate aminotransferase (EC:2.6.1.44); AGT

Protein Family

Serine--pyruvate aminotransferase

UniProt Gene Name

Agxt

UniProt Synonym Gene Names

Agxt1; SPT; AGT

UniProt Entry Name

SPYA_MOUSE

NCBI Protein Information

serine--pyruvate aminotransferase, mitochondrial; serine--pyruvate aminotransferase, peroxisomal

UniProt Comments for Agxt

AGXT: Defects in AGXT are the cause of hyperoxaluria primary type 1 (HP1); also known as primary hyperoxaluria type I (PH1) and oxalosis I. HP1 is a rare autosomal recessive inborn error of glyoxylate metabolism characterized by increased excretion of oxalate and glycolate, and the progressive accumulation of insoluble calcium oxalate in the kidney and urinary tract. Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.

Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; Mitochondrial; EC 2.6.1.51; Motility/polarity/chemotaxis; Transferase; EC 2.6.1.44; Amino Acid Metabolism - glycine, serine and threonine

Cellular Component: mitochondrial matrix; mitochondrion; peroxisomal matrix; peroxisome

Molecular Function: alanine-glyoxylate transaminase activity; amino acid binding; catalytic activity; protein homodimerization activity; protein self-association; pyridoxal phosphate binding; receptor binding; serine-pyruvate transaminase activity; transaminase activity; transferase activity

Biological Process: glycine biosynthetic process, by transamination of glyoxylate; glyoxylate catabolic process; glyoxylate metabolic process; L-alanine catabolic process; L-cysteine catabolic process; Notch signaling pathway; oxalic acid secretion; proteasomal protein catabolic process; pyruvate biosynthetic process; response to cAMP; response to glucocorticoid stimulus

Research Articles on Agxt

1. expressed wild-type human AGT1 was predominantly localized in mouse hepatocellular peroxisomes, whereas the most common mutant form of AGT1 (G170R) was localized predominantly in the mitochondria

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Agxt antibody

Reference Product	PubMed Publications
Grhpr antibody	>13 publications with Agxt and Grhpr
Gldc antibody	>1 publications with Agxt and Gldc

Pathways associated with anti-Agxt antibody

Products by Pathway	Pathway Diagram
Alanine And Aspartate Metabolism Pathway antibodies	Alanine And Aspartate Metabolism Pathway Diagram
Alanine, Aspartate And Glutamate Metabolism Pathway antibodies	Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
Alanine, Aspartate And Glutamate Metabolism Pathway antibodies	Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
Carbon Metabolism Pathway antibodies	Carbon Metabolism Pathway Diagram
Carbon Metabolism Pathway antibodies	Carbon Metabolism Pathway Diagram
Glycine, Serine And Threonine Metabolism Pathway antibodies	Glycine, Serine And Threonine Metabolism Pathway Diagram
Glycine, Serine And Threonine Metabolism Pathway antibodies	Glycine, Serine And Threonine Metabolism Pathway Diagram
Glyoxylate And Dicarboxylate Metabolism Pathway antibodies	Glyoxylate And Dicarboxylate Metabolism Pathway Diagram
Glyoxylate And Dicarboxylate Metabolism Pathway antibodies	Glyoxylate And Dicarboxylate Metabolism Pathway Diagram
Glyoxylate Metabolism And Glycine Degradation Pathway antibodies	Glyoxylate Metabolism And Glycine Degradation Pathway Diagram

Diseases associated with anti-Agxt antibody

Disease Name	Pubmed Publications
Kidney Diseases Antibodies	>76 publications with Agxt and Kidney Diseases
Primary hyperoxaluria type 1 Antibodies	>63 publications with Agxt and Primary hyperoxaluria type 1
Liver Diseases Antibodies	>7 publications with Agxt and Liver Diseases
Neoplasms, Experimental Antibodies	>3 publications with Agxt and Neoplasms, Experimental
Hypertension Antibodies	>3 publications with Agxt and Hypertension
Nervous System Diseases Antibodies	>3 publications with Agxt and Nervous System Diseases
Cardiovascular Diseases Antibodies	>2 publications with Agxt and Cardiovascular Diseases
Neurotoxicity Syndromes Antibodies	>1 publications with Agxt and Neurotoxicity Syndromes
Poisoning Antibodies	>1 publications with Agxt and Poisoning
Fatty Liver Antibodies	>1 publications with Agxt and Fatty Liver

Organs/Tissues associated with anti-Agxt antibody

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>46 publications with Agxt and Liver