Retinal Dehydrogenase 2 (ALDH1A2) Antibody – Rabbit Polyclonal

This protein belongs to the aldehyde dehydrogenase family of proteins. The product of this gene is an enzyme that catalyzes the synthesis of retinoic acid (RA) from retinaldehyde. Retinoic acid, the active derivative of vitamin A (retinol), is a hormonal signaling molecule that functions in developing and adult tissues. The studies of a similar mouse gene suggest that this enzyme and the cytochrome CYP26A1, concurrently establish local embryonic retinoic acid levels which facilitate posterior organ development and prevent spina bifida. Four transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2011]

ALDH1A2: Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently. Belongs to the aldehyde dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; Cofactor and Vitamin Metabolism - retinol; EC 1.2.1.36

Chromosomal Location of Human Ortholog: 15q21.3

Cellular Component: cytoplasm; cytosol; perinuclear region of cytoplasm

Molecular Function: 3-chloroallyl aldehyde dehydrogenase activity; aldehyde dehydrogenase (NAD) activity; retinal binding; retinal dehydrogenase activity

Biological Process: 9-cis-retinoic acid biosynthetic process; anterior/posterior pattern formation; blood vessel development; cardiac muscle development; determination of bilateral symmetry; embryonic camera-type eye development; embryonic forelimb morphogenesis; embryonic gut development; heart morphogenesis; hindbrain development; kidney development; liver development; lung development; midgut development; morphogenesis of embryonic epithelium; negative regulation of cell proliferation; neural crest cell development; neural tube development; neuron differentiation; pancreas development; pituitary gland development; positive regulation of apoptosis; positive regulation of cell proliferation; proximal/distal pattern formation; regulation of endothelial cell proliferation; response to cytokine stimulus; response to estradiol stimulus; response to vitamin A; retinal metabolic process; retinoic acid metabolic process; retinoic acid receptor signaling pathway; retinol metabolic process; vitamin A metabolic process