Rabbit Anti-ETHE1 Polyclonal Antibody – Cat# MBS1493277

ETHE1 Antibody – Rabbit Polyclonal

Name: ETHE1 Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS1493277
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1493277

Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the… More details

$230 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ETHE1, Polyclonal Antibody

Full Product Name

ETHE1 Antibody, Biotin conjugated

Product Gene Name

anti-ETHE1 antibody

Product Synonym Names

Persulfide dioxygenase ETHE1; mitochondrial (EC:1.13.11.182 Publications; ETHE1; HSCO; Ethylmalonic encephalopathy protein 1; Hepatoma subtracted clone one protein; Sulfur dioxygenase ETHE1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse

Purity/Purification

>95%, Protein G Purified

Preparation and Storage

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Matching Pairs

Unconjugated Antibody: ETHE1 (MBS7006162)
Biotin Conjugated Antibody: ETHE1 (MBS1493277)

Molecular Weight

27,873 Da

OMIM

602473

3D Structure

ModBase 3D Structure for O95571

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Conjugate

Biotin

Immunogen

Recombinant human Persulfide dioxygenase ETHE1, mitochondrial protein

Santa Cruz Alternative

Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-161566

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-ETHE1 antibody

ELISA (EIA)

Other Notes

Small volumes of anti-ETHE1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ETHE1 purchase

MBS1493277 is an antibody targeting ETHE1. Also known as ETHE1 Antibody, Biotin conjugated. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ETHE1. It may not necessarily be applicable to this product.

NCBI GI #

41327741

NCBI GeneID

23474

NCBI Accession #

NP_055112.2

UniProt Primary Accession #

O95571

UniProt Secondary Accession #

Q96HR0; Q9H001

UniProt Related Accession #

O95571

GenBank Nucleotide #

NM_014297.3

NCBI Official Full Name

persulfide dioxygenase ETHE1, mitochondrial

NCBI Official Synonym Full Names

ethylmalonic encephalopathy 1

NCBI Official Symbol

ETHE1

NCBI Official Synonym Symbols

HSCO; YF13H12

UniProt Protein Name

Persulfide dioxygenase ETHE1, mitochondrial

UniProt Synonym Protein Names

Ethylmalonic encephalopathy protein 1; Hepatoma subtracted clone one protein; Sulfur dioxygenase ETHE1

Protein Family

Persulfide dioxygenase

UniProt Gene Name

ETHE1

UniProt Synonym Gene Names

HSCO

UniProt Entry Name

ETHE1_HUMAN

NCBI Protein Information

persulfide dioxygenase ETHE1, mitochondrial

NCBI Summary for ETHE1

This gene encodes a sulfur dioxygenase that localizes within the mitochondrial matrix. The enzyme functions in sulfide catabolism. Mutations in this gene result in ethylmalonic encephalopathy.[provided by RefSeq, May 2009]

UniProt Comments for ETHE1

ETHE1: Probably plays an important role in metabolic homeostasis in mitochondria. May function as a nuclear-cytoplasmic shuttling protein that binds transcription factor RELA/NFKB3 in the nucleus and exports it to the cytoplasm. Suppresses p53- induced apoptosis by preventing nuclear localization of RELA. Defects in ETHE1 are a cause of ethylmalonic encephalopathy (EE). EE is an autosomal recessive disorder characterized by neurodevelopmental delay and regression, recurrent petechiae, acrocyanosis, diarrhea, leading to death in the first decade of life. It is also associated with persistent lactic acidemia and ethylmalonic and methylsuccinic aciduria. Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.

Protein type: Mitochondrial; EC 1.13.11.18; Hydrolase

Chromosomal Location of Human Ortholog: 19q13.31

Cellular Component: cytoplasm; mitochondrial matrix; mitochondrion; nucleoplasm

Molecular Function: iron ion binding; sulfur dioxygenase activity

Biological Process: glutathione metabolic process; sulfur amino acid catabolic process; sulfur amino acid metabolic process

Disease: Encephalopathy, Ethylmalonic

Research Articles on ETHE1

1. ETHE1 R163W/R163Q mutations are associated with Ethylmalonic encephalopathy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ETHE1 antibody

Reference Product	PubMed Publications
TST antibody	>4 publications with ETHE1 and TST
SQRDL antibody	>2 publications with ETHE1 and SQRDL
HDAC1 antibody	>1 publications with ETHE1 and HDAC1
RELA antibody	>1 publications with ETHE1 and RELA

Pathways associated with anti-ETHE1 antibody

Products by Pathway	Pathway Diagram
Degradation Of Cysteine And Homocysteine Pathway antibodies	Degradation Of Cysteine And Homocysteine Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Amino Acids And Derivatives Pathway antibodies	Metabolism Of Amino Acids And Derivatives Pathway Diagram
Sulfide Oxidation To Sulfate Pathway antibodies	Sulfide Oxidation To Sulfate Pathway Diagram
Sulfur Amino Acid Metabolism Pathway antibodies	Sulfur Amino Acid Metabolism Pathway Diagram
Sulfur Metabolism Pathway antibodies	Sulfur Metabolism Pathway Diagram
Sulfur Metabolism Pathway antibodies	Sulfur Metabolism Pathway Diagram

Diseases associated with anti-ETHE1 antibody

Disease Name	Pubmed Publications
Ethylmalonic encephalopathy Antibodies	>38 publications with ETHE1 and Ethylmalonic encephalopathy
Nervous System Diseases Antibodies	>22 publications with ETHE1 and Nervous System Diseases
Blood Coagulation Disorders Antibodies	>11 publications with ETHE1 and Blood Coagulation Disorders
Hemorrhage Antibodies	>11 publications with ETHE1 and Hemorrhage
Liver Diseases Antibodies	>4 publications with ETHE1 and Liver Diseases
Fatty Liver Antibodies	>3 publications with ETHE1 and Fatty Liver
Atrophy Antibodies	>2 publications with ETHE1 and Atrophy
Inflammation Antibodies	>2 publications with ETHE1 and Inflammation
Proteinuria Antibodies	>1 publications with ETHE1 and Proteinuria
Kidney Diseases Antibodies	>1 publications with ETHE1 and Kidney Diseases

Organs/Tissues associated with anti-ETHE1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>28 publications with ETHE1 and Brain
Liver Antibodies	>8 publications with ETHE1 and Liver
Muscle Antibodies	>8 publications with ETHE1 and Muscle
Blood Antibodies	>8 publications with ETHE1 and Blood
Skin Antibodies	>4 publications with ETHE1 and Skin
Kidney Antibodies	>3 publications with ETHE1 and Kidney
Heart Antibodies	>2 publications with ETHE1 and Heart
Connective Tissue Antibodies	>1 publications with ETHE1 and Connective Tissue
Intestine Antibodies	>1 publications with ETHE1 and Intestine