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Heat Shock Protein 105 Kda (HSPH1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1493496

Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities More details

$230 / 0.05 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Heat shock protein 105 kDa (HSPH1), Polyclonal Antibody
Full Product Name
Rabbit anti-human Heat shock protein 105 kDa polyclonal Antibody(HSPH1)
Product Gene Name
anti-HSPH1 antibody
Product Synonym Names
Antigen NY-CO-25; Heat shock 110 kDa protein; HSPH1; HSP105; HSP110; KIAA0201
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
Antigen Affinity Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Molecular Weight
97,460 Da
OMIM
610703
3D Structure
ModBase 3D Structure for Q92598
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Heat shock protein 105 kDa protein (659-858aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-1804 / sc-6241
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-HSPH1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-HSPH1 antibody
Recommended dilution: WB:1:500-2000
IHC:1:20-1:200

Western Blot (WB) of anti-HSPH1 antibody

All lanes: Heat shock protein 105 kDa
antibody at 1ug/ml
Lane 1:MCF-7 whole cell lysate
Lane 2:Hela whole cell lysate
Lane 3:mouse brain tissue
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 97,93,98 kDa
Observed band size: 97 kDa
Rabbit Anti-HSPH1 Polyclonal Antibody – Cat# MBS1493496

Immunohistochemistry (IHC) of anti-HSPH1 antibody

Immunohistochemistry of paraffin-embedded human liver cancer using MBS1493496 at dilution 1:100
Rabbit Anti-HSPH1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1493496

Other Notes

Small volumes of anti-HSPH1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HSPH1 purchase

MBS1493496 is an antibody targeting HSPH1. Also known as Rabbit anti-human Heat shock protein 105 kDa polyclonal Antibody(HSPH1). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HSPH1. It may not necessarily be applicable to this product.

NCBI GI #
557357685
NCBI GeneID
10808
NCBI Accession #
NP_001273432.1
UniProt Primary Accession #
Q92598
UniProt Secondary Accession #
O95739; Q5TBM6; Q5TBM7; Q5TBM8; Q9UPC4; B4DYH1
UniProt Related Accession #
Q92598
GenBank Nucleotide #
NM_001286503.1
NCBI Official Full Name
heat shock protein 105 kDa isoform 2
NCBI Official Synonym Full Names
heat shock protein family H (Hsp110) member 1
NCBI Official Symbol
HSPH1
NCBI Official Synonym Symbols
HSP105; HSP105A; HSP105B; NY-CO-25
UniProt Protein Name
Heat shock protein 105 kDa
UniProt Synonym Protein Names
Antigen NY-CO-25; Heat shock 110 kDa protein
Protein Family
Heat shock protein
UniProt Gene Name
HSPH1
UniProt Synonym Gene Names
HSP105; HSP110; KIAA0201
UniProt Entry Name
HS105_HUMAN
NCBI Protein Information
heat shock protein 105 kDa

UniProt Comments for HSPH1

HSP105: a molecular chaperone of the heat shock protein 70 family. Has ATPase activity. Expressed at especially high levels in mammalian brain and has been shown to suppress apoptosis in neuronal cells and to prevent the aggregation of proteins following heat shock. Known to interact with a variety of proteins including alpha-tubulin and the androgen receptor. Two alternatively spliced isoforms have been described.

Protein type: Chaperone; Heat shock protein

Chromosomal Location of Human Ortholog: 13q12.3

Cellular Component: cytoplasm; cytosol; extracellular region; microtubule; nucleoplasm

Molecular Function: alpha-tubulin binding; ATP binding; protein binding

Biological Process: chaperone cofactor-dependent protein folding; positive regulation of MHC class I biosynthetic process; positive regulation of NK T cell activation; positive regulation of transcription from RNA polymerase II promoter; receptor-mediated endocytosis; response to unfolded protein
Show more

Research Articles on HSPH1

1. About 25% of patients with stages II-III colorectal tumors with microsatellite instability have an excellent response to chemotherapy, due to large, biallelic deletions in the T(17) intron repeat of HSP110 in tumor DNA.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HSPH1 antibody

 Reference Product  PubMed Publications
 DNAJB1 antibody  >8 publications with HSPH1 and DNAJB1
 HSPA8 antibody  >5 publications with HSPH1 and HSPA8
 HSP90AB1 antibody  >1 publications with HSPH1 and HSP90AB1
 HSP90AA1 antibody  >1 publications with HSPH1 and HSP90AA1

Pathways associated with anti-HSPH1 antibody

 Products by Pathway  Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Cellular Response To Heat Stress Pathway antibodies  Cellular Response To Heat Stress Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Protein Processing In Endoplasmic Reticulum Pathway antibodies  Protein Processing In Endoplasmic Reticulum Pathway Diagram
 Regulation Of HSF1-mediated Heat Shock Response Pathway antibodies  Regulation Of HSF1-mediated Heat Shock Response Pathway Diagram
 Scavenging By Class F Receptors Pathway antibodies  Scavenging By Class F Receptors Pathway Diagram
 Vesicle-mediated Transport Pathway antibodies  Vesicle-mediated Transport Pathway Diagram

Diseases associated with anti-HSPH1 antibody

 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >7 publications with HSPH1 and Adenocarcinoma
 Disease Models, Animal Antibodies  >3 publications with HSPH1 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >3 publications with HSPH1 and Cardiovascular Diseases
 Inflammation Antibodies  >3 publications with HSPH1 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >2 publications with HSPH1 and Carcinoma, Hepatocellular
 Heart Diseases Antibodies  >2 publications with HSPH1 and Heart Diseases
 Necrosis Antibodies  >2 publications with HSPH1 and Necrosis
 Fibrosis Antibodies  >1 publications with HSPH1 and Fibrosis
 Lung Neoplasms Antibodies  >1 publications with HSPH1 and Lung Neoplasms
 Liver Diseases Antibodies  >1 publications with HSPH1 and Liver Diseases

Organs/Tissues associated with anti-HSPH1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with HSPH1 and Blood
 Skin Antibodies  >7 publications with HSPH1 and Skin
 Brain Antibodies  >7 publications with HSPH1 and Brain
 Liver Antibodies  >3 publications with HSPH1 and Liver
 Lymph Node Antibodies  >3 publications with HSPH1 and Lymph Node
 Lymph Antibodies  >3 publications with HSPH1 and Lymph
 Testis Antibodies  >3 publications with HSPH1 and Testis
 Intestine Antibodies  >2 publications with HSPH1 and Intestine
 Bone Antibodies  >2 publications with HSPH1 and Bone
 Lung Antibodies  >2 publications with HSPH1 and Lung
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