S1PR1 Antibody – Rabbit Polyclonal

The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. [provided by RefSeq, Jul 2008]

EDG-1: a G protein-coupled receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Highly expressed in endothelial cells and to a lesser extent, in vascular smooth muscle cells, fibroblasts, melanocytes, and cells of epithelioid origin. Suggested to be involved in the processes that regulate the migration/differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. S1P-induced endothelial cell migration requires AKT1-mediated phosphorylation of the third intracellular loop. Seems to be coupled to the G(i) subclass of heteromeric G proteins.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 1p21

Cellular Component: cytosol; endosome; external side of plasma membrane; integral to membrane; intrinsic to plasma membrane; lipid raft; plasma membrane

Molecular Function: G-protein coupled receptor activity; G-protein-coupled receptor binding; sphingolipid binding

Biological Process: actin cytoskeleton reorganization; angiogenesis; blood vessel maturation; brain development; cell adhesion; cell migration; chemotaxis; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); endothelial cell differentiation; G-protein coupled receptor protein signaling pathway; G-protein signaling, adenylate cyclase inhibiting pathway; lamellipodium biogenesis; negative regulation of stress fiber formation; neuron differentiation; positive regulation of cell migration; positive regulation of GTPase activity; positive regulation of positive chemotaxis; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; regulation of bone mineralization; regulation of bone resorption; regulation of cell adhesion; transmission of nerve impulse