Intermediate Conductance Calcium-Activated Potassium Channel Protein 4 (KCNN4) Antibody – Rabbit Polyclonal

The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]

KCNN4: Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily.

Protein type: Channel, potassium; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: apical plasma membrane; basolateral plasma membrane; cell soma; lipid raft; plasma membrane; voltage-gated potassium channel complex

Molecular Function: calcium-activated potassium channel activity; calmodulin binding; Intermediate conductance calcium-activated potassium channel activity; protein binding; protein phosphatase binding; small conductance calcium-activated potassium channel activity

Biological Process: calcium ion transport; cell volume homeostasis; defense response; immune system process; phospholipid translocation; positive regulation of protein secretion; positive regulation of T cell receptor signaling pathway; potassium ion transport; saliva secretion; stabilization of membrane potential; synaptic transmission