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CHD1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1493929

ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA… More details

$230 / 0.05 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CHD1, Polyclonal Antibody
Full Product Name
CHD1 Antibody
Product Gene Name
anti-CHD1 antibody
Product Synonym Names
CHD-1; ATP-dependent helicase CHD1; CHD1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Molecular Weight
196,590 Da
OMIM
602118
3D Structure
ModBase 3D Structure for O14646
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Chromodomain-helicase-DNA-binding protein 1 protein (1501-1710aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-49810 / sc-49813 / sc-134751
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CHD1 antibody
ELISA (EIA), Immunohistochemistry (IHC), Chromatin Immunoprecipitation (ChIP)
Application Notes for anti-CHD1 antibody
Recommended dilution: IHC:1:20-1:200

Immunohistochemistry (IHC) of anti-CHD1 antibody

Immunohistochemistry of paraffin-embedded human breast cancer using MBS1493929 at dilution 1:100
Rabbit Anti-CHD1 Polyclonal Antibody – Cat# MBS1493929

Immunohistochemistry (IHC) of anti-CHD1 antibody

Immunohistochemistry of paraffin-embedded human placenta tissue using MBS1493929 at dilution 1:100
Rabbit Anti-CHD1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1493929

Immunohistochemistry (IHC) of anti-CHD1 antibody

Immunohistochemistry of paraffin-embedded human colon cancer using MBS1493929 at dilution 1:100
Rabbit Anti-CHD1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1493929

Chromatin Immunoprecipitation (ChIP) of anti-CHD1 antibody

Chromatin Immunoprecipitation Hela(1.1^106)were cross-linked with formaldehyde, sonicated, and immunoprecipitated with 4ug anti-CDH1 or a control normal rabbit IgG . The resulting ChIP DNA was quantified using real-time PCR with primers against the RPL30 promoter.
Rabbit Anti-CHD1 Polyclonal Antibody, Chromatin Immunoprecipitation (ChIP) – Cat# MBS1493929

Other Notes

Small volumes of anti-CHD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CHD1 purchase

MBS1493929 is an antibody targeting CHD1. Also known as CHD1 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CHD1. It may not necessarily be applicable to this product.

NCBI GI #
68299795
NCBI GeneID
1105
NCBI Accession #
NP_001261.2
UniProt Primary Accession #
O14646
UniProt Secondary Accession #
Q17RZ3
UniProt Related Accession #
O14646
GenBank Nucleotide #
NM_001270.2
NCBI Official Full Name
chromodomain-helicase-DNA-binding protein 1
NCBI Official Synonym Full Names
chromodomain helicase DNA binding protein 1
NCBI Official Symbol
CHD1
UniProt Protein Name
Chromodomain-helicase-DNA-binding protein 1
UniProt Synonym Protein Names
ATP-dependent helicase CHD1
Protein Family
Chromodomain-helicase-DNA-binding protein
UniProt Gene Name
CHD1
UniProt Synonym Gene Names
CHD-1
UniProt Entry Name
CHD1_HUMAN
NCBI Protein Information
chromodomain-helicase-DNA-binding protein 1

NCBI Summary for CHD1

The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. [provided by RefSeq, Jul 2008]
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UniProt Comments for CHD1

CHD-1: a sequence-selective DNA-binding protein. Contains two chromo (chromatin organization modifier) domains and one SNF2-related helicase and ATPase domains. May play an important role in gene regulation.

Protein type: EC 3.6.4.12; Helicase

Chromosomal Location of Human Ortholog: 5q15-q21

Cellular Component: cytoplasm; nucleus

Molecular Function: ATP binding; ATP-dependent DNA helicase activity; DNA binding; methylated histone residue binding; protein binding

Biological Process: chromatin modification; DNA duplex unwinding; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent
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Research Articles on CHD1

1. The double chromodomains of CHD1 adopt an 'open pocket' to interact with the free N-terminal amine of H3K4, and the open pocket permits the NS1 mimic to bind in a distinct conformation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CHD1 antibody

 Reference Product  PubMed Publications
 PAF1 antibody  >6 publications with CHD1 and PAF1
 RTF1 antibody  >4 publications with CHD1 and RTF1
 SSRP1 antibody  >2 publications with CHD1 and SSRP1
 SUPT16H antibody  >1 publications with CHD1 and SUPT16H

Diseases associated with anti-CHD1 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >7 publications with CHD1 and Breast Neoplasms
 Adenocarcinoma Antibodies  >2 publications with CHD1 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >2 publications with CHD1 and Neoplasms, Experimental
 Heart Diseases Antibodies  >2 publications with CHD1 and Heart Diseases
 Nervous System Diseases Antibodies  >2 publications with CHD1 and Nervous System Diseases
 Lung Diseases Antibodies  >1 publications with CHD1 and Lung Diseases
 Liver Diseases Antibodies  >1 publications with CHD1 and Liver Diseases
 Anemia Antibodies  >1 publications with CHD1 and Anemia
 Carcinoma, Hepatocellular Antibodies  >1 publications with CHD1 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with CHD1 and Liver Neoplasms

Organs/Tissues associated with anti-CHD1 antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >17 publications with CHD1 and Prostate
 Blood Antibodies  >11 publications with CHD1 and Blood
 Skin Antibodies  >3 publications with CHD1 and Skin
 Embryonic Tissue Antibodies  >3 publications with CHD1 and Embryonic Tissue
 Stomach Antibodies  >3 publications with CHD1 and Stomach
 Bone Antibodies  >3 publications with CHD1 and Bone
 Heart Antibodies  >3 publications with CHD1 and Heart
 Brain Antibodies  >3 publications with CHD1 and Brain
 Intestine Antibodies  >2 publications with CHD1 and Intestine
 Bone Marrow Antibodies  >2 publications with CHD1 and Bone Marrow
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