Synaptosomal-Associated Protein 25 (SNAP25) Antibody – Rabbit Polyclonal

Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the other two. Therefore, this gene product is a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

SNAP-25: a presynaptic plasma membrane protein involved in the regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Part of the SNARE core complex containing SNAP25, VAMP2 and syntaxin 1A. Associates with proteins involved in vesicle docking and membrane fusion. Two alternatively spliced isoforms have been described.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 20p12-p11.2

Cellular Component: cell junction; cytoplasm; cytosol; growth cone; membrane; myelin sheath; neuron projection; perinuclear region of cytoplasm; plasma membrane; presynaptic membrane; SNARE complex; trans-Golgi network; vesicle; voltage-gated potassium channel complex

Molecular Function: calcium-dependent protein binding; protein binding; SNAP receptor activity; syntaxin-1 binding

Biological Process: associative learning; energy reserve metabolic process; glutamate secretion; locomotory behavior; neurotransmitter secretion; neurotransmitter uptake; regulation of insulin secretion; synaptic transmission; synaptic vesicle docking during exocytosis; synaptic vesicle exocytosis; synaptic vesicle fusion to presynaptic membrane; synaptic vesicle priming

Disease: Myasthenic Syndrome, Congenital, 18