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Nitrogen Permease Regulator 2-Like Protein (NPRL2) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1494278

Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues. May act as a tumor… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Nitrogen permease regulator 2-like protein (NPRL2), Polyclonal Antibody
Full Product Name
Rabbit anti-human Nitrogen permease regulator 2-like protein polyclonal Antibody(NPRL2)
Product Gene Name
anti-NPRL2 antibody
Product Synonym Names
NPR2-like protein; Gene 21 protein; G21 protein; Tumor suppressor candidate 4; NPRL2; TUSC4
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
Antigen Affinity Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Molecular Weight
23,150 Da
OMIM
607072
3D Structure
ModBase 3D Structure for Q8WTW4
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Nitrogen permease regulator 2-like protein (1-220aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-54487 / sc-54638 / sc-292095
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-NPRL2 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-NPRL2 antibody
Recommended dilution: WB:1:500-2000
IHC:1:20-1:200

Western Blot (WB) of anti-NPRL2 antibody

All lanes: Nitrogen permease regulator 2-like protein antibody at 7ug/ml+mouse skeletal muscle tissue
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 44,24 kDa
Observed band size: 44 kDa
Rabbit Anti-NPRL2 Polyclonal Antibody – Cat# MBS1494278

Immunohistochemistry (IHC) of anti-NPRL2 antibody

Immunohistochemistry of paraffin-embedded human rectum using MBS1494278 at dilution 1:100
Rabbit Anti-NPRL2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1494278

Immunohistochemistry (IHC) of anti-NPRL2 antibody

Immunohistochemistry of paraffin-embedded human lung cancer using MBS1494278 at dilution 1:100
Rabbit Anti-NPRL2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1494278

Other Notes

Small volumes of anti-NPRL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NPRL2 purchase

MBS1494278 is an antibody targeting NPRL2. Also known as Rabbit anti-human Nitrogen permease regulator 2-like protein polyclonal Antibody(NPRL2). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NPRL2. It may not necessarily be applicable to this product.

NCBI GI #
50592992
NCBI GeneID
10641
NCBI Accession #
NP_006536.3
UniProt Primary Accession #
Q8WTW4
UniProt Secondary Accession #
Q6FGS2; Q9Y249; Q9Y497; A8K831
UniProt Related Accession #
Q8WTW4
GenBank Nucleotide #
NM_006545.4
NCBI Official Full Name
nitrogen permease regulator 2-like protein
NCBI Official Synonym Full Names
NPR2-like, GATOR1 complex subunit
NCBI Official Symbol
NPRL2
NCBI Official Synonym Symbols
NPR2; NPR2L; TUSC4
UniProt Protein Name
Nitrogen permease regulator 2-like protein
UniProt Synonym Protein Names
Gene 21 protein; G21 protein; Tumor suppressor candidate 4
Protein Family
Nitrogen permease regulator 2-like protein
UniProt Gene Name
NPRL2
UniProt Synonym Gene Names
TUSC4; NPR2-like protein; G21 protein
UniProt Entry Name
NPRL2_HUMAN
NCBI Protein Information
nitrogen permease regulator 2-like protein

UniProt Comments for NPRL2

NPRL2: Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs. Belongs to the NPR2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Inhibitor; Tumor suppressor

Chromosomal Location of Human Ortholog: 3p21.3

Molecular Function: GTPase activator activity; protein binding; protein kinase activity

Biological Process: cellular response to amino acid starvation; negative regulation of kinase activity; negative regulation of TOR signaling pathway; positive regulation of GTPase activity; protein amino acid phosphorylation
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Research Articles on NPRL2

1. NPRL2 enhances sensitivity to oxaliplatin in colon cancer cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NPRL2 antibody

 Reference Product  PubMed Publications
 NPRL3 antibody  >8 publications with NPRL2 and NPRL3
 CACNA2D2 antibody  >4 publications with NPRL2 and CACNA2D2
 DEPDC5 antibody  >3 publications with NPRL2 and DEPDC5
 ZMYND10 antibody  >2 publications with NPRL2 and ZMYND10
 TUSC2 antibody  >1 publications with NPRL2 and TUSC2

Diseases associated with anti-NPRL2 antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >3 publications with NPRL2 and Kidney Diseases
 Neoplasm Metastasis Antibodies  >2 publications with NPRL2 and Neoplasm Metastasis
 Liver Diseases Antibodies  >2 publications with NPRL2 and Liver Diseases
 Liver Neoplasms Antibodies  >2 publications with NPRL2 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >2 publications with NPRL2 and Carcinoma, Hepatocellular
 Nervous System Diseases Antibodies  >1 publications with NPRL2 and Nervous System Diseases
 Lymphoma Antibodies  >1 publications with NPRL2 and Lymphoma
 Abnormalities, Multiple Antibodies  >1 publications with NPRL2 and Abnormalities, Multiple
 Neoplasms, Experimental Antibodies  >1 publications with NPRL2 and Neoplasms, Experimental

Organs/Tissues associated with anti-NPRL2 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >11 publications with NPRL2 and Lung
 Kidney Antibodies  >4 publications with NPRL2 and Kidney
 Liver Antibodies  >4 publications with NPRL2 and Liver
 Blood Antibodies  >2 publications with NPRL2 and Blood
 Lymph Node Antibodies  >2 publications with NPRL2 and Lymph Node
 Lymph Antibodies  >2 publications with NPRL2 and Lymph
 Embryonic Tissue Antibodies  >1 publications with NPRL2 and Embryonic Tissue
 Pancreas Antibodies  >1 publications with NPRL2 and Pancreas
 Stomach Antibodies  >1 publications with NPRL2 and Stomach
 Pharynx Antibodies  >1 publications with NPRL2 and Pharynx
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