YKT6 Antibody – Rabbit Polyclonal

This gene product is one of the SNARE recognition molecules implicated in vesicular transport between secretory compartments. It is a membrane associated, isoprenylated protein that functions at the endoplasmic reticulum-Golgi transport step. This protein is highly conserved from yeast to human and can functionally complement the loss of the yeast homolog in the yeast secretory pathway. [provided by RefSeq, Jul 2008]

YKT6: Vesicular soluble NSF attachment protein receptor (v- SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. Belongs to the synaptobrevin family.

Protein type: Transferase; EC 2.3.1.-; Membrane protein, integral; Vesicle; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 7p15.1

Cellular Component: cell soma; cytoplasm; cytoplasmic vesicle membrane; cytosol; endoplasmic reticulum; endosome; ER-Golgi intermediate compartment membrane; Golgi apparatus; Golgi membrane; integral to plasma membrane; mitochondrion; SNARE complex; transport vesicle

Molecular Function: protein-cysteine S-palmitoleyltransferase activity; SNAP receptor activity; SNARE binding

Biological Process: cellular protein metabolic process; ER to Golgi vesicle-mediated transport; post-translational protein modification; protein amino acid N-linked glycosylation via asparagine; protein transport; retrograde transport, endosome to Golgi; vesicle docking during exocytosis; vesicle fusion; vesicle targeting