Rabbit Anti-TBX22 Polyclonal Antibody – Cat# MBS1494738

Immunohistochemistry of paraffin-embedded human tonsil using MBS1494738 at dilution 1:100

T-Box Transcription Factor TBX22 (TBX22) Antibody – Rabbit Polyclonal

Name: TBX22 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS1494738
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1494738

Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis. More details

$230 / 0.05 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

T-box transcription factor TBX22, Polyclonal Antibody

Full Product Name

Rabbit anti-human T-box transcription factor TBX22 polyclonal Antibody(TBX22)

Product Gene Name

anti-TBX22 antibody

Product Synonym Names

T-box protein 22; TBX22; TBOX22

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Purity/Purification

Antigen Affinity Purified

Preparation and Storage

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Molecular Weight

44,718 Da

OMIM

300307

3D Structure

ModBase 3D Structure for Q9Y458

Storage Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Conjugate

Non-conjugated

Immunogen

Recombinant human T-box transcription factor TBX22 protein (291-520aa)

Santa Cruz Alternative

Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-17862 / sc-17861

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-TBX22 antibody

ELISA (EIA), Immunohistochemistry (IHC)

Application Notes for anti-TBX22 antibody

Recommended dilution: IHC:1:20-1:200

Other Notes

Small volumes of anti-TBX22 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TBX22 purchase

MBS1494738 is an antibody targeting TBX22. Also known as Rabbit anti-human T-box transcription factor TBX22 polyclonal Antibody(TBX22). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TBX22. It may not necessarily be applicable to this product.

NCBI GI #

158187509

NCBI GeneID

50945

NCBI Accession #

NP_001103348.1

UniProt Primary Accession #

Q9Y458

UniProt Secondary Accession #

Q5JZ06; Q96LC0; Q9HBF1

UniProt Related Accession #

Q9Y458

GenBank Nucleotide #

NM_001109878.1

NCBI Official Full Name

T-box transcription factor TBX22 isoform 1

NCBI Official Synonym Full Names

T-box 22

NCBI Official Symbol

TBX22

NCBI Official Synonym Symbols

CPX; CLPA; TBXX; ABERS; dJ795G23.1

UniProt Protein Name

T-box transcription factor TBX22

Protein Family

T-box transcription factor

UniProt Gene Name

TBX22

UniProt Synonym Gene Names

TBOX22; T-box protein 22

UniProt Entry Name

TBX22_HUMAN

NCBI Protein Information

T-box transcription factor TBX22

NCBI Summary for TBX22

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene have been associated with the inherited X-linked disorder, Cleft palate with ankyloglossia, and it is believed to play a major role in human palatogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for TBX22

TBX22: Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis. Defects in TBX22 are the cause of X-linked cleft palate with ankyloglossia (CPX). 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: Xq21.1

Cellular Component: nucleus

Molecular Function: DNA binding; protein binding; transcription factor activity

Biological Process: multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; regulation of transcription, DNA-dependent; transcription, DNA-dependent

Disease: Abruzzo-erickson Syndrome; Cleft Palate With Or Without Ankyloglossia, X-linked

Research Articles on TBX22

1. These results suggest that a loss-of-function mutation in the X-linked TBX22 promoter may cause the cleft palate through disruption of TBX22-ETS-1 pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TBX22 antibody

Reference Product	PubMed Publications
SMCP antibody	>1 publications with TBX22 and SMCP

Diseases associated with anti-TBX22 antibody

Disease Name	Pubmed Publications
Congenital Abnormalities Antibodies	>31 publications with TBX22 and Congenital Abnormalities
Chromosome Aberrations Antibodies	>6 publications with TBX22 and Chromosome Aberrations
Disease Models, Animal Antibodies	>2 publications with TBX22 and Disease Models, Animal
Heart Defects, Congenital Antibodies	>1 publications with TBX22 and Heart Defects, Congenital
Neurobehavioral Manifestations Antibodies	>1 publications with TBX22 and Neurobehavioral Manifestations
Cleft palate X-linked Antibodies	>1 publications with TBX22 and Cleft palate X-linked

Organs/Tissues associated with anti-TBX22 antibody

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>1 publications with TBX22 and Skin