Nt-3 Growth Factor Receptor (NTRK3) Antibody – Rabbit Polyclonal

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

TrkC: a receptor tyrosine kinase of the TRK family. Receptor for neurotrophin-3 (NT-3). Known substrates for the trk receptors are SHC, PI-3 kinase, and PLCG1. Four alternatively spliced isoforms are known.

Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, tyrosine (receptor); Protein kinase, TK; TK group; Trk family

Chromosomal Location of Human Ortholog: 15q25

Cellular Component: cytoplasm; integral to plasma membrane; receptor complex

Molecular Function: ATP binding; GPI-linked ephrin receptor activity; neurotrophin binding; neurotrophin receptor activity; p53 binding; protein binding

Biological Process: activation of MAPK activity; activation of protein kinase B; circadian rhythm; ephrin receptor signaling pathway; heart development; mechanoreceptor differentiation; modification by virus of host cell transcription; negative regulation of astrocyte differentiation; negative regulation of protein amino acid phosphorylation; neuron fate specification; neuron migration; peptidyl-tyrosine phosphorylation; positive regulation of apoptosis; positive regulation of axon extension involved in regeneration; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of peptidyl-serine phosphorylation; positive regulation of positive chemotaxis; positive regulation of protein amino acid phosphorylation; positive regulation of synaptogenesis; protein amino acid autophosphorylation; response to axon injury; response to corticosterone stimulus; response to ethanol; transmembrane receptor protein tyrosine kinase signaling pathway