Dynactin Subunit 3 (DCTN3) Antibody – Rabbit Polyclonal

This gene encodes the smallest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, cytokinesis, chromosome movement, nuclear positioning, and axonogenesis. This subunit, like most other dynactin subunits, exists only as a part of the dynactin complex. It is primarily an alpha-helical protein with very little coiled coil, and binds directly to the largest subunit (p150) of dynactin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

dynactin 3: Together with dynein may be involved in spindle assembly and cytokinesis. Belongs to the dynactin subunit 3 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Microtubule-binding; Motor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: centrosome; cleavage furrow; cytosol; dynactin complex; midbody; perinuclear region of cytoplasm; spindle

Molecular Function: protein binding; structural molecule activity

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; cellular protein metabolic process; cytokinesis; ER to Golgi vesicle-mediated transport; G2/M transition of mitotic cell cycle; microtubule-based process; mitosis; mitotic cell cycle; organelle organization and biogenesis; post-translational protein modification; protein amino acid N-linked glycosylation via asparagine