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TTLL5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1495016

Polyglutamylase which preferentially modifies alpha-tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step (By similarity). Required for CCSAP localization to both spindle and cilia… More details

$230 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TTLL5, Polyclonal Antibody
Full Product Name
TTLL5 Antibody
Product Gene Name
anti-TTLL5 antibody
Product Synonym Names
Tubulin polyglutamylase TTLL5 (EC:6.-.-.-); TTLL5; KIAA0998; STAMP; SRC1 and TIF2-associated modulatory protein; Tubulin--tyrosine ligase-like protein 5
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
>95%, Protein G Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Matching Pairs
Unconjugated Antibody: TTLL5 (MBS1495016)
HRP Conjugated Antibody: TTLL5 (MBS1494511)
Matching Pairs
Unconjugated Antibody: TTLL5 (MBS1495016)
FITC Conjugated Antibody: TTLL5 (MBS1496215)
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Molecular Weight
31,401 Da
OMIM
612268
3D Structure
ModBase 3D Structure for Q6EMB2
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
Non-conjugated
Immunogen
Recombinant human Tubulin polyglutamylase TTLL5 protein
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-244538
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-TTLL5 antibody
ELISA (EIA)

Other Notes

Small volumes of anti-TTLL5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TTLL5 purchase

MBS1495016 is an antibody targeting TTLL5. Also known as TTLL5 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TTLL5. It may not necessarily be applicable to this product.

NCBI GI #
50658079
NCBI GeneID
23093
NCBI Accession #
NP_055887.3
UniProt Primary Accession #
Q6EMB2
UniProt Secondary Accession #
Q9BUB0; Q9H0G4; Q9H7W2; Q9P1V5; Q9UPZ4; B9EGH8; B9EGH9
UniProt Related Accession #
Q6EMB2
GenBank Nucleotide #
NM_015072.4
NCBI Official Full Name
tubulin polyglutamylase TTLL5
NCBI Official Synonym Full Names
tubulin tyrosine ligase like 5
NCBI Official Symbol
TTLL5
NCBI Official Synonym Symbols
STAMP; CORD19; KIAA0998
UniProt Protein Name
Tubulin polyglutamylase TTLL5
UniProt Synonym Protein Names
SRC1 and TIF2-associated modulatory protein; Tubulin--tyrosine ligase-like protein 5
Protein Family
Tubulin polyglutamylase
UniProt Gene Name
TTLL5
UniProt Synonym Gene Names
KIAA0998; STAMP
UniProt Entry Name
TTLL5_HUMAN
NCBI Protein Information
tubulin polyglutamylase TTLL5

NCBI Summary for TTLL5

This gene encodes a member of the tubulin tyrosine ligase like protein family. This protein interacts with two glucocorticoid receptor coactivators, transcriptional intermediary factor 2 and steroid receptor coactivator 1. This protein may function as a coregulator of glucocorticoid receptor mediated gene induction and repression. This protein may also function as an alpha tubulin polyglutamylase.[provided by RefSeq, Feb 2010]
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UniProt Comments for TTLL5

TTLL5: Polyglutamylase which preferentially modifies alpha- tubulin. Involved in the side-chain initiation step of the polyglutamylation reaction rather than in the elongation step. Required for CCSAP localization to both spindle and cilia microtubules. Increases the effects of NCOA2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction. Belongs to the tubulin--tyrosine ligase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Ligase; EC 6.-.-.-; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: centrosome; cilium; cytoplasm; microtubule; nucleus

Molecular Function: ATP binding; ligase activity

Biological Process: fertilization; protein polyglutamylation; sperm axoneme assembly; sperm motility; transcription, DNA-dependent

Disease: Cone-rod Dystrophy 19
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Research Articles on TTLL5

1. this study has performed exome sequencing in 28 individuals with a similar disease phenotype and subsequently used a casecontrol approach to identify mutations in TTLL5 as a cause of recessive retinal dystrophy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TTLL5 antibody

 Reference Product  PubMed Publications
 NCOA2 antibody  >3 publications with TTLL5 and NCOA2
 NCOA1 antibody  >2 publications with TTLL5 and NCOA1

Diseases associated with anti-TTLL5 antibody

 Disease Name  Pubmed Publications
 Genital Diseases, Female Antibodies  >2 publications with TTLL5 and Genital Diseases, Female
 Male Urogenital Diseases Antibodies  >1 publications with TTLL5 and Male Urogenital Diseases

Organs/Tissues associated with anti-TTLL5 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >2 publications with TTLL5 and Kidney
 Eye Antibodies  >1 publications with TTLL5 and Eye
 Testis Antibodies  >1 publications with TTLL5 and Testis
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