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Protein LYRIC (MTDH) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1495120

Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor… More details

$230 / 0.05 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Protein LYRIC (MTDH), Polyclonal Antibody
Full Product Name
Rabbit anti-human Protein LYRIC polyclonal Antibody(MTDH)
Product Gene Name
anti-MTDH antibody
Product Synonym Names
3D3/LYRIC; Astrocyte elevated gene-1 protein; AEG-1; Lysine-rich CEACAM1 co-isolated protein; Metadherin; Metastasis adhesion protein; MTDH; AEG1; LYRIC
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Molecular Weight
63,837 Da
OMIM
610323
3D Structure
ModBase 3D Structure for Q86UE4
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Protein LYRIC protein (1-260aa)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-MTDH antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP)
Application Notes for anti-MTDH antibody
Recommended dilution: IHC:1:20-1:200

Immunohistochemistry (IHC) of anti-MTDH antibody

Immunohistochemistry of paraffin-embedded human breast cancer using MBS1495120 at dilution 1:100
Rabbit Anti-MTDH Polyclonal Antibody – Cat# MBS1495120

Immunohistochemistry (IHC) of anti-MTDH antibody

Immunohistochemistry of paraffin-embedded human tonsil using MBS1495120 at dilution 1:100
Rabbit Anti-MTDH Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1495120

Immunoprecipitation (IP) of anti-MTDH antibody

Immunoprecipitating MTDH in Hela whole cell lysate
Lane 1: Rabbit monoclonal IgG(1ug)instead of MBS1495120 in Hela whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000)
Lane 2: MBS1495120(4ug)+ Hela whole cell lysate(500ug)
Lane 3: Hela whole cell lysate (20ug)
Rabbit Anti-MTDH Polyclonal Antibody, Immunoprecipitation (IP) – Cat# MBS1495120

Other Notes

Small volumes of anti-MTDH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MTDH purchase

MBS1495120 is an antibody targeting MTDH. Also known as Rabbit anti-human Protein LYRIC polyclonal Antibody(MTDH). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MTDH. It may not necessarily be applicable to this product.

NCBI GI #
223555917
NCBI GeneID
92140
NCBI Accession #
NP_848927.2
UniProt Primary Accession #
Q86UE4
UniProt Secondary Accession #
Q05DH2; Q52QU9; Q6PK07; Q8TCX3
UniProt Related Accession #
Q86UE4
GenBank Nucleotide #
NM_178812.3
NCBI Official Full Name
protein LYRIC
NCBI Official Synonym Full Names
metadherin
NCBI Official Symbol
MTDH
NCBI Official Synonym Symbols
3D3; AEG1; AEG-1; LYRIC; LYRIC/3D3
UniProt Protein Name
Protein LYRIC
UniProt Synonym Protein Names
3D3/LYRIC; Astrocyte elevated gene-1 protein; AEG-1; Lysine-rich CEACAM1 co-isolated protein; Metadherin; Metastasis adhesion protein
Protein Family
Protein LYRIC
UniProt Gene Name
MTDH
UniProt Synonym Gene Names
AEG1; LYRIC; AEG-1
UniProt Entry Name
LYRIC_HUMAN
NCBI Protein Information
protein LYRIC

UniProt Comments for MTDH

Lyric: a protein of unknown function.

Protein type: Nucleolus; Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 8q22.1

Cellular Component: apical plasma membrane; cytoplasm; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; intercellular canaliculus; nuclear body; nuclear membrane; nucleolus; nucleus; perinuclear region of cytoplasm; tight junction

Molecular Function: double-stranded RNA binding; NF-kappaB binding; protein binding; transcription coactivator activity

Biological Process: activation of NF-kappaB transcription factor; lipopolysaccharide-mediated signaling pathway; negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; positive regulation of angiogenesis; positive regulation of autophagy; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of protein kinase B signaling cascade
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Research Articles on MTDH

1. ectopic miR-217 expression decreased AEG-1 expression and repressed luciferase reporter activity associated with the AEG-1 3'-untranslated region (UTR).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MTDH antibody

 Reference Product  PubMed Publications
 MYC antibody  >23 publications with MTDH and MYC
 SLC1A2 antibody  >3 publications with MTDH and SLC1A2
 FOXO3 antibody  >3 publications with MTDH and FOXO3
 MAX antibody  >2 publications with MTDH and MAX
 RRS1 antibody  >1 publications with MTDH and RRS1
 MMP1 antibody  >1 publications with MTDH and MMP1

Pathways associated with anti-MTDH antibody

 Products by Pathway  Pathway Diagram
 Gastric Cancer Network 2 Pathway antibodies  Gastric Cancer Network 2 Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Activation Pathway antibodies  Validated Targets Of C-MYC Transcriptional Activation Pathway Diagram

Diseases associated with anti-MTDH antibody

 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >70 publications with MTDH and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >56 publications with MTDH and Breast Neoplasms
 Liver Neoplasms Antibodies  >35 publications with MTDH and Liver Neoplasms
 Liver Diseases Antibodies  >31 publications with MTDH and Liver Diseases
 Death Antibodies  >22 publications with MTDH and Death
 Brain Diseases Antibodies  >18 publications with MTDH and Brain Diseases
 Nervous System Diseases Antibodies  >17 publications with MTDH and Nervous System Diseases
 Disease Models, Animal Antibodies  >14 publications with MTDH and Disease Models, Animal
 Necrosis Antibodies  >11 publications with MTDH and Necrosis
 Inflammation Antibodies  >8 publications with MTDH and Inflammation

Organs/Tissues associated with anti-MTDH antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >39 publications with MTDH and Liver
 Lymph Antibodies  >32 publications with MTDH and Lymph
 Lung Antibodies  >30 publications with MTDH and Lung
 Lymph Node Antibodies  >30 publications with MTDH and Lymph Node
 Brain Antibodies  >20 publications with MTDH and Brain
 Prostate Antibodies  >17 publications with MTDH and Prostate
 Blood Antibodies  >16 publications with MTDH and Blood
 Vascular Antibodies  >13 publications with MTDH and Vascular
 Kidney Antibodies  >8 publications with MTDH and Kidney
 Stomach Antibodies  >8 publications with MTDH and Stomach
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