TIMM10 Antibody – Rabbit Polyclonal

The mitochondrial protein encoded by this gene belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane, functioning as intermembrane space chaperones for the highly insoluble carrier proteins. [provided by RefSeq, Nov 2011]

TIMM10: Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. Belongs to the small Tim family.

Protein type: Mitochondrial

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: mitochondrial inner membrane; mitochondrial inner membrane presequence translocase complex; mitochondrial intermembrane space; mitochondrial intermembrane space protein transporter complex; mitochondrion

Molecular Function: chaperone binding; protein binding; protein homodimerization activity; protein transporter activity; transporter activity; zinc ion binding

Biological Process: cellular protein metabolic process; protein import into mitochondrial inner membrane; protein targeting to mitochondrion; sensory perception of sound