Cell Division Cycle 5-Like Protein (CDC5L) Antibody – Rabbit Polyclonal

The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008]

CDC5L: is a spliceosome protein that binds DNA and that also regulates transcription. Is a positive regulator of cell cycle G2/M progression. Is an essential component of non-snRNA spliceosomes and is required for the second catalytic step of pre-mRNA splicing. Binds adeno-pre-mRNA in an ATP-stimulated manner. Is part of a spliceosomal 'core' complex that includes CDC5L, SF2, PRLI, SPF27, HSP7C, PRPF19/SNEV, GCN1L. Identified in the spliceosome C complex. Has been associated with aneuploidy in aging cells and in tumorigenesis. The genomic region containing the gene for CDC5L (6p21.1) is frequently amplified in osteosarcomas.

Protein type: RNA processing; Transcription factor; Motility/polarity/chemotaxis; RNA splicing; DNA-binding; Spliceosome

Chromosomal Location of Human Ortholog: 6p21

Cellular Component: cytoplasm; DNA replication factor A complex; membrane; nuclear speck; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm

Molecular Function: DNA binding; leucine zipper domain binding; protein binding; protein kinase binding; protein phosphatase 1 binding

Biological Process: DNA repair; gene expression; mitotic cell cycle; nuclear mRNA splicing, via spliceosome; regulation of transcription, DNA-dependent; RNA splicing; transcription, DNA-dependent