ATP6V1B2 Antibody – Rabbit Polyclonal

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts. [provided by RefSeq, Jul 2008]

ATP6V1B2: Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the ATPase alpha/beta chains family.

Protein type: EC 3.6.3.14; Hydrolase; Energy Metabolism - oxidative phosphorylation

Chromosomal Location of Human Ortholog: 8p21.3

Cellular Component: cytosol; endomembrane system; integral to membrane; intracellular membrane-bound organelle; lysosomal membrane; melanosome; microvillus; myelin sheath; plasma membrane; ruffle

Molecular Function: ATP binding; hydrogen ion transmembrane transporter activity; hydrogen ion transporting ATPase activity, rotational mechanism; protein binding

Biological Process: ATP hydrolysis coupled proton transport; ATP metabolic process; cell redox homeostasis; cellular iron ion homeostasis; insulin receptor signaling pathway; proton transport; transferrin transport; transmembrane transport

Disease: Zimmermann-laband Syndrome 2