3-Phosphoinositide-Dependent Protein Kinase 1 (PDPK1) Antibody – Rabbit Polyclonal

PDK1: an AGC kinase of the PKB family that contains a PH domain. Involved in a wide variety of processes including cell proliferation, differentiation and apoptosis. Autophosphorylation in the activation loop is necessary for activity. Phosphorylates and activates kinases including Akt, PKC isozymes, p70 S6K and RSK. Three alternatively-spliced isoforms have been described.

Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, AGC; Kinase, protein; Nuclear receptor co-regulator; AGC group; PKB family

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: cell projection; cytoplasm; cytoplasmic membrane-bound vesicle; cytosol; focal adhesion; intracellular; membrane; nucleoplasm; plasma membrane

Molecular Function: 3-phosphoinositide-dependent protein kinase activity; ATP binding; insulin receptor binding; phospholipase activator activity; phospholipase binding; protein binding; protein kinase binding; protein serine/threonine kinase activity

Biological Process: actin cytoskeleton organization and biogenesis; activation of protein kinase B; blood coagulation; calcium-mediated signaling; cell migration; cellular response to insulin stimulus; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; focal adhesion formation; hyperosmotic response; innate immune response; insulin receptor signaling pathway; negative regulation of protein kinase activity; negative regulation of toll-like receptor signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; nerve growth factor receptor signaling pathway; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphoinositide-mediated signaling; platelet activation; positive regulation of release of sequestered calcium ion into cytosol; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of I-kappaB kinase/NF-kappaB cascade; regulation of mast cell degranulation; regulation of transcription, DNA-dependent; small GTPase mediated signal transduction; stimulatory C-type lectin receptor signaling pathway; synaptic transmission; T cell costimulation; T cell receptor signaling pathway; transcription, DNA-dependent; vascular endothelial growth factor receptor signaling pathway