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MED28 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1495992

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase… More details

$230 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MED28, Polyclonal Antibody
Full Product Name
MED28 Antibody
Product Gene Name
anti-MED28 antibody
Product Synonym Names
Mediator of RNA polymerase II transcription subunit 28; MED28; EG1; FKSG20; Endothelial-derived protein 1; Mediator complex subunit 28; Merlin and Grb2-interacting cytoskeletal protein; Magicin; Tumor angiogenesis marker EG-1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
>95%, Protein G Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Matching Pairs
Unconjugated Antibody: MED28 (MBS1495992)
Biotin Conjugated Antibody: MED28 (MBS1494619)
Matching Pairs
Unconjugated Antibody: MED28 (MBS1495992)
FITC Conjugated Antibody: MED28 (MBS1496326)
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Molecular Weight
19,520 Da
OMIM
610311
3D Structure
ModBase 3D Structure for Q9H204
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
Non-conjugated
Immunogen
Recombinant human Mediator of RNA polymerase II transcription subunit 28 protein
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-104372
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-MED28 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-MED28 antibody
Recommended dilution: IHC:1:20-1:200

Immunohistochemistry (IHC) of anti-MED28 antibody

Immunohistochemistry of paraffin-embedded human testis tissue using MBS1495992 at dilution of 1:100
Rabbit Anti-MED28 Polyclonal Antibody – Cat# MBS1495992

Immunohistochemistry (IHC) of anti-MED28 antibody

Immunohistochemistry of paraffin-embedded human breast cancer using MBS1495992 at dilution of 1:100
Rabbit Anti-MED28 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1495992

Other Notes

Small volumes of anti-MED28 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MED28 purchase

MBS1495992 is an antibody targeting MED28. Also known as MED28 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MED28. It may not necessarily be applicable to this product.

NCBI GI #
52851391
NCBI GeneID
80306
NCBI Accession #
NP_079481.2
UniProt Primary Accession #
Q9H204
UniProt Secondary Accession #
Q9BZJ5
UniProt Related Accession #
Q9H204
GenBank Nucleotide #
NM_025205.4
NCBI Official Full Name
mediator of RNA polymerase II transcription subunit 28
NCBI Official Synonym Full Names
mediator complex subunit 28
NCBI Official Symbol
MED28
NCBI Official Synonym Symbols
EG1; magicin; 1500003D12Rik
UniProt Protein Name
Mediator of RNA polymerase II transcription subunit 28
UniProt Synonym Protein Names
Endothelial-derived protein 1; Mediator complex subunit 28; Merlin and Grb2-interacting cytoskeletal protein; Magicin; Tumor angiogenesis marker EG-1
Protein Family
Mediator of RNA polymerase II transcription
UniProt Gene Name
MED28
UniProt Synonym Gene Names
EG1; Magicin
UniProt Entry Name
MED28_HUMAN
NCBI Protein Information
mediator of RNA polymerase II transcription subunit 28

UniProt Comments for MED28

MED28: a component of the mediator complex that can either repress or activate transcription. Mediator complexes are essential for basal and regulated expression of nearly all RNA polymerase II-dependent genes. They may act as a bridge, conveying regulatory information from enhancers and other control elements to the promoter. May be part of a complex containing NF2/Merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways. Up-regulated by endothelial cells when exposed to tumor conditioned media.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 4p16

Cellular Component: cortical actin cytoskeleton; membrane; Srb-mediator complex

Molecular Function: actin binding; protein binding

Biological Process: negative regulation of smooth muscle cell differentiation; regulation of transcription, DNA-dependent; stem cell maintenance; transcription, DNA-dependent
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Research Articles on MED28

1. This paper describes a link between Med23 and IFN-lambda3, provides evidence for the crucial role of IFN-lambda in HSV-1 immune control.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MED28 antibody

 Reference Product  PubMed Publications
 MED10 antibody  >2 publications with MED28 and MED10
 MED26 antibody  >2 publications with MED28 and MED26
 MED4 antibody  >1 publications with MED28 and MED4
 MED19 antibody  >1 publications with MED28 and MED19
 MED21 antibody  >1 publications with MED28 and MED21
 MED30 antibody  >1 publications with MED28 and MED30
 MED27 antibody  >1 publications with MED28 and MED27
 MED29 antibody  >1 publications with MED28 and MED29

Pathways associated with anti-MED28 antibody

 Products by Pathway  Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PPARA Activates Gene Expression Pathway antibodies  PPARA Activates Gene Expression Pathway Diagram
 Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway antibodies  Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway Diagram
 Transcriptional Regulation Of White Adipocyte Differentiation Pathway antibodies  Transcriptional Regulation Of White Adipocyte Differentiation Pathway Diagram

Diseases associated with anti-MED28 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >8 publications with MED28 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >2 publications with MED28 and Neoplasms, Experimental
 Adenocarcinoma Antibodies  >1 publications with MED28 and Adenocarcinoma
 Lung Neoplasms Antibodies  >1 publications with MED28 and Lung Neoplasms
 Neoplasm Invasiveness Antibodies  >1 publications with MED28 and Neoplasm Invasiveness
 Inflammation Antibodies  >1 publications with MED28 and Inflammation
 Neoplasm Metastasis Antibodies  >1 publications with MED28 and Neoplasm Metastasis
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