Protachykinin-1 (TAC1) Antibody – Rabbit Polyclonal

This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Substance P is an antimicrobial peptide with antibacterial and antifungal properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

TAC1: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Belongs to the tachykinin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7q21-q22

Cellular Component: axon; cell soma; cytosol; extracellular region; extracellular space; plasma membrane

Molecular Function: protein binding; receptor binding; substance P receptor binding

Biological Process: antibacterial humoral response; antifungal humoral response; associative learning; cell-cell signaling; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; detection of abiotic stimulus; elevation of cytosolic calcium ion concentration; inflammatory response; innate immune response; insemination; long-term memory; negative regulation of heart rate; neuropeptide signaling pathway; positive regulation of action potential; positive regulation of acute inflammatory response; positive regulation of lymphocyte proliferation; positive regulation of ossification; positive regulation of saliva secretion; positive regulation of stress fiber formation; positive regulation of synaptic transmission, cholinergic; positive regulation of synaptic transmission, GABAergic; regulation of blood pressure; response to hormone stimulus; response to lipopolysaccharide; response to morphine; response to pain; response to yeast; sensory perception of pain; synaptic transmission; tachykinin signaling pathway