SOD3 Antibody – Rabbit Polyclonal

This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk. [provided by RefSeq, Oct 2015]

SOD3: Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen. Belongs to the Cu-Zn superoxide dismutase family.

Protein type: Secreted, signal peptide; Oxidoreductase; Secreted; EC 1.15.1.1

Chromosomal Location of Human Ortholog: 4p15.2

Cellular Component: cytoplasm; extracellular matrix; extracellular region; extracellular space; Golgi lumen; nucleus; trans-Golgi network

Molecular Function: copper ion binding; heparin binding; protein binding; superoxide dismutase activity; zinc ion binding

Biological Process: removal of superoxide radicals; response to copper ion; response to hypoxia; response to reactive oxygen species