A-Kinase Anchor Protein 5 (AKAP5) Antibody – Rabbit Polyclonal

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq, Jul 2008]

AKAP5: May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Binding protein for dimer of the RII-beta regulatory subunit of cAMP-dependent protein kinase (PKA) and also for the protein kinase C (PKC) and the phosphatase calcineurin (PP2B). Each enzyme is inhibited when bound to the anchoring protein. Also binds the beta2-adrenergic receptor. Part of a complex containing AKAP5, ADCY5, ADCY6 AND PDE4C. Interacts with ADCY8, and enhances its phosphorylation at lipid rafts. Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 14q23.3

Cellular Component: asymmetric synapse; basolateral plasma membrane; cell soma; cytoskeleton; cytosol; dendritic shaft; dendritic spine; filopodium membrane; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; protein complex

Molecular Function: actin binding; adenylate cyclase binding; cadherin binding; calmodulin binding; G-protein-coupled receptor binding; GABA receptor binding; protein binding; protein complex binding; protein domain specific binding; protein kinase A binding; protein kinase binding; protein phosphatase 2B binding

Biological Process: cellular protein complex disassembly; energy reserve metabolic process; hippocampus development; maternal process involved in pregnancy; negative regulation of adenylate cyclase activity; negative regulation of potassium ion transport; positive regulation of adenylate cyclase activity; positive regulation of cAMP biosynthetic process; positive regulation of dendrite morphogenesis; positive regulation of NFAT protein import into nucleus; positive regulation of protein amino acid phosphorylation; protein targeting; regulation of insulin secretion; response to electrical stimulus; response to muscle activity; signal transduction; spinal cord development; synaptic transmission