Serine/Threonine-Protein Kinase PLK2 (PLK2) Antibody – Rabbit Polyclonal

The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

PLK2: a kinase of the PLK family. Participates in a mitotic checkpoint in which p53-dependent activation Plk2 prevents mitotic catastrophe following spindle damage. Plk2(-/-) embryos show retarded growth and skeletal development late in gestation. Apparently plays a role for Plk2 in the cell cycle.

Protein type: EC 2.7.11.21; Protein kinase, Other; Kinase, protein; Tumor suppressor; Protein kinase, Ser/Thr (non-receptor); Other group; PLK family

Chromosomal Location of Human Ortholog: 5q12.1-q13.2

Cellular Component: centriole; centrosome; chromatin; cytoplasm; dendrite; intracellular

Molecular Function: ATP binding; ATP-dependent protein binding; protein binding; protein complex binding; protein serine/threonine kinase activity; signal transducer activity

Biological Process: G1/S transition of mitotic cell cycle; memory; mitotic cell cycle checkpoint; mitotic spindle organization and biogenesis; negative regulation of apoptosis; peptidyl-serine phosphorylation; positive regulation of autophagy; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein binding; positive regulation of protein catabolic process; protein amino acid phosphorylation; Rap protein signal transduction; Ras protein signal transduction; regulation of centriole replication; regulation of synaptic plasticity