DCTN2 Antibody – Rabbit Polyclonal

This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2012]

dynactin 2: Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development. Belongs to the dynactin subunit 2 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Cell cycle regulation; Motor; Microtubule-binding

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: centrosome; cytoplasm; cytosol; dynactin complex; dynein complex; growth cone; kinetochore; membrane; microtubule; vesicle

Molecular Function: motor activity; protein binding; spectrin binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; cell proliferation; cellular protein metabolic process; ER to Golgi vesicle-mediated transport; G2/M transition of mitotic cell cycle; melanosome transport; mitosis; mitotic cell cycle; mitotic spindle organization and biogenesis; organelle organization and biogenesis; post-translational protein modification; protein amino acid N-linked glycosylation via asparagine