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Evolutionarily Conserved Signaling Intermediate in Toll Pathway (ECSIT) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1496885

Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By… More details

$230 / 0.05 mL +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
Evolutionarily conserved signaling intermediate in Toll pathway (ECSIT), Polyclonal Antibody
Full Product Name
Rabbit anti-human Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial polyclonal Antibody(ECSIT)
Product Gene Name
anti-ECSIT antibody
Product Synonym Names
Protein SITPEC; ECSIT
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Molecular Weight
33,938 Da
OMIM
608388
3D Structure
ModBase 3D Structure for Q9BQ95
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial protein (185-431aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-79473 / sc-79470 / sc-133535 / sc-98508
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-ECSIT antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ECSIT antibody
Recommended dilution: WB:1:500-2000
IHC:1:20-1:200

Western Blot (WB) of anti-ECSIT antibody

All lanes: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial antibody at 10ug/ml+jurkat whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 50,34,25 kDa
Observed band size: 49 kDa
Rabbit Anti-ECSIT Polyclonal Antibody – Cat# MBS1496885

Immunohistochemistry (IHC) of anti-ECSIT antibody

Immunohistochemistry of paraffin-embedded human small intestine using MBS1496885 at dilution 1:100
Rabbit Anti-ECSIT Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1496885

Immunohistochemistry (IHC) of anti-ECSIT antibody

Immunohistochemistry of paraffin-embedded human testis using MBS1496885 at dilution 1:100
Rabbit Anti-ECSIT Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1496885

Other Notes

Small volumes of anti-ECSIT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ECSIT purchase

MBS1496885 is an antibody targeting ECSIT. Also known as Rabbit anti-human Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial polyclonal Antibody(ECSIT). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ECSIT. It may not necessarily be applicable to this product.

NCBI GI #
215599065
NCBI GeneID
51295
NCBI Accession #
NP_001135936.1
UniProt Primary Accession #
Q9BQ95
UniProt Secondary Accession #
Q96HQ7; Q9NYI1; E9PAN9; K7EMM0
UniProt Related Accession #
Q9BQ95
GenBank Nucleotide #
NM_001142464.2
NCBI Official Full Name
evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform 2
NCBI Official Synonym Full Names
ECSIT signalling integrator
NCBI Official Symbol
ECSIT
NCBI Official Synonym Symbols
SITPEC
UniProt Protein Name
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial
UniProt Synonym Protein Names
Protein SITPEC
Protein Family
Evolutionarily conserved signaling intermediate
UniProt Gene Name
ECSIT
UniProt Entry Name
ECSIT_HUMAN
NCBI Protein Information
evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

UniProt Comments for ECSIT

ECSIT: Adapter protein of the Toll-like and IL-1 receptor signaling pathway that is involved in the activation of NF-kappa-B via MAP3K1. Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development. Required for efficient assembly of mitochondrial NADH:ubiquinone oxidoreductase. Belongs to the ECSIT family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Transcription factor

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: cytoplasm; mitochondrial inner membrane; mitochondrion; nucleoplasm; nucleus

Molecular Function: oxidoreductase activity, acting on NADH or NADPH; protein binding

Biological Process: cellular metabolic process; innate immune response; mitochondrial respiratory chain complex I assembly; regulation of oxidoreductase activity
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Research Articles on ECSIT

1. mediates virus-triggered type I IFN induction by bridging RIG-I and MDA5 to the VISA complex

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ECSIT antibody

 Reference Product  PubMed Publications
 TRAF6 antibody  >5 publications with ECSIT and TRAF6
 NDUFAF1 antibody  >3 publications with ECSIT and NDUFAF1
 MAP3K1 antibody  >2 publications with ECSIT and MAP3K1
 IRAK2 antibody  >1 publications with ECSIT and IRAK2
 TRIM59 antibody  >1 publications with ECSIT and TRIM59

Pathways associated with anti-ECSIT antibody

 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Complex I Biogenesis Pathway antibodies  Complex I Biogenesis Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 MyD88 Cascade Initiated On Plasma Membrane Pathway antibodies  MyD88 Cascade Initiated On Plasma Membrane Pathway Diagram
 MyD88 Dependent Cascade Initiated On Endosome Pathway antibodies  MyD88 Dependent Cascade Initiated On Endosome Pathway Diagram

Diseases associated with anti-ECSIT antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with ECSIT and Nervous System Diseases
 Inflammation Antibodies  >5 publications with ECSIT and Inflammation
 Neurodegenerative Diseases Antibodies  >4 publications with ECSIT and Neurodegenerative Diseases
 Necrosis Antibodies  >2 publications with ECSIT and Necrosis
 Neurobehavioral Manifestations Antibodies  >1 publications with ECSIT and Neurobehavioral Manifestations
 Edema Antibodies  >1 publications with ECSIT and Edema
 Heart Diseases Antibodies  >1 publications with ECSIT and Heart Diseases

Organs/Tissues associated with anti-ECSIT antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >6 publications with ECSIT and Bone
 Heart Antibodies  >3 publications with ECSIT and Heart
 Brain Antibodies  >2 publications with ECSIT and Brain
 Pancreas Antibodies  >1 publications with ECSIT and Pancreas
 Kidney Antibodies  >1 publications with ECSIT and Kidney
 Stomach Antibodies  >1 publications with ECSIT and Stomach
 Liver Antibodies  >1 publications with ECSIT and Liver
 Embryonic Tissue Antibodies  >1 publications with ECSIT and Embryonic Tissue
 Intestine Antibodies  >1 publications with ECSIT and Intestine
 Lymph Antibodies  >1 publications with ECSIT and Lymph
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