Rabbit Anti-PRKRA Polyclonal Antibody – Cat# MBS1497035

PRKRA Antibody – Rabbit Polyclonal

Name: PRKRA Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS1497035
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1497035

Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated… More details

$230 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PRKRA, Polyclonal Antibody

Full Product Name

PRKRA Antibody, Biotin conjugated

Product Gene Name

anti-PRKRA antibody

Product Synonym Names

Interferon-inducible double-stranded RNA-dependent protein kinase activator A; PRKRA; PACT; RAX; HSD-14; HSD14; PKR-associated protein X; PKR-associating protein X; Protein activator of the interferon-induced protein kinase; Protein kinase; interferon-inducible double-stranded RNA-dependent activator

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Purity/Purification

>95%, Protein G Purified

Preparation and Storage

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Matching Pairs

Unconjugated Antibody: PRKRA (MBS7002196)
Biotin Conjugated Antibody: PRKRA (MBS1497035)

Molecular Weight

31,635 Da

OMIM

603424

3D Structure

ModBase 3D Structure for O75569

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Conjugate

Biotin

Immunogen

Recombinant human Interferon-inducible double-stranded RNA-dependent protein kinase activator A protein

Santa Cruz Alternative

Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-18768 / sc-32010 / sc-292629

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-PRKRA antibody

ELISA (EIA)

Other Notes

Small volumes of anti-PRKRA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRKRA purchase

MBS1497035 is an antibody targeting PRKRA. Also known as PRKRA Antibody, Biotin conjugated. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PRKRA. It may not necessarily be applicable to this product.

NCBI GI #

213417911

NCBI GeneID

8575

NCBI Accession #

NP_001132989.1

UniProt Primary Accession #

O75569

UniProt Secondary Accession #

Q53G24; Q6X7T5; Q8NDK4; A8K3I6

UniProt Related Accession #

O75569

GenBank Nucleotide #

NM_001139517.1

NCBI Official Full Name

interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform 2

NCBI Official Synonym Full Names

protein activator of interferon induced protein kinase EIF2AK2

NCBI Official Symbol

PRKRA

NCBI Official Synonym Symbols

RAX; PACT; DYT16; HSD14

UniProt Protein Name

Interferon-inducible double-stranded RNA-dependent protein kinase activator A

UniProt Synonym Protein Names

PKR-associated protein X; PKR-associating protein X; Protein activator of the interferon-induced protein kinase; Protein kinase, interferon-inducible double-stranded RNA-dependent activator

Protein Family

Interferon-inducible double-stranded RNA-dependent protein kinase activator

UniProt Gene Name

PRKRA

UniProt Synonym Gene Names

PACT; RAX

UniProt Entry Name

PRKRA_HUMAN

NCBI Protein Information

interferon-inducible double-stranded RNA-dependent protein kinase activator A

NCBI Summary for PRKRA

This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

UniProt Comments for PRKRA

PACT: a double strand RNA binding protein (dsRBP). Interacts with TRBP and Dicer to stimulate the cleavage of double-stranded or short hairpin RNA to siRNA. Appears to have a pro-apoptotic function that may be suppressed in the presence of growth factor. Activates the interferon-induced protein kinase PKR. Three alternatively spliced human isoforms have been reported.

Protein type: RNA processing; Activator; RNA-binding

Chromosomal Location of Human Ortholog: 2q31.2

Cellular Component: cytoplasm; cytosol; membrane; nucleoplasm; perinuclear region of cytoplasm

Molecular Function: double-stranded RNA binding; enzyme activator activity; enzyme binding; identical protein binding; protein binding; protein homodimerization activity

Biological Process: gene expression; immune response; middle ear morphogenesis; miRNA-mediated gene silencing, production of miRNAs; negative regulation of cell proliferation; outer ear morphogenesis; positive regulation of catalytic activity; pre-microRNA processing; protein amino acid phosphorylation; response to virus; RNA interference, production of siRNA; RNA-mediated gene silencing; skeletal morphogenesis

Disease: Dystonia 16

Research Articles on PRKRA

1. this study demonstrates for the first time that OV20.0 of Orf virus is also able to interact with the dsRNA binding domain of PACT and that the presence of dsRNA strengthened the interaction of these two molecules.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PRKRA antibody

Reference Product	PubMed Publications
DICER1 antibody	>9 publications with PRKRA and DICER1
EIF2C2 antibody	>6 publications with PRKRA and EIF2C2
TARBP2 antibody	>5 publications with PRKRA and TARBP2
ADAR antibody	>1 publications with PRKRA and ADAR
EIF2AK2 antibody	>1 publications with PRKRA and EIF2AK2

Pathways associated with anti-PRKRA antibody

Products by Pathway	Pathway Diagram
Ceramide Signaling Pathway antibodies	Ceramide Signaling Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Gene Silencing By RNA Pathway antibodies	Gene Silencing By RNA Pathway Diagram
MicroRNA (miRNA) Biogenesis Pathway antibodies	MicroRNA (miRNA) Biogenesis Pathway Diagram
Small Interfering RNA (siRNA) Biogenesis Pathway antibodies	Small Interfering RNA (siRNA) Biogenesis Pathway Diagram

Diseases associated with anti-PRKRA antibody

Disease Name	Pubmed Publications
Dystonia Antibodies	>20 publications with PRKRA and Dystonia
Dystonic Disorders Antibodies	>14 publications with PRKRA and Dystonic Disorders
Brain Diseases Antibodies	>13 publications with PRKRA and Brain Diseases
Parkinsonian Disorders Antibodies	>5 publications with PRKRA and Parkinsonian Disorders
Craniofacial Abnormalities Antibodies	>3 publications with PRKRA and Craniofacial Abnormalities
Precancerous Conditions Antibodies	>2 publications with PRKRA and Precancerous Conditions
Disease Models, Animal Antibodies	>2 publications with PRKRA and Disease Models, Animal
Cognition Disorders Antibodies	>1 publications with PRKRA and Cognition Disorders
Hyperplasia Antibodies	>1 publications with PRKRA and Hyperplasia
Inflammation Antibodies	>1 publications with PRKRA and Inflammation

Organs/Tissues associated with anti-PRKRA antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>12 publications with PRKRA and Brain
Ear Antibodies	>7 publications with PRKRA and Ear
Blood Antibodies	>7 publications with PRKRA and Blood
Liver Antibodies	>5 publications with PRKRA and Liver
Muscle Antibodies	>4 publications with PRKRA and Muscle
Ganglia Antibodies	>4 publications with PRKRA and Ganglia
Skin Antibodies	>2 publications with PRKRA and Skin
Ovary Antibodies	>2 publications with PRKRA and Ovary
Bone Antibodies	>2 publications with PRKRA and Bone
Eye Antibodies	>2 publications with PRKRA and Eye