Regulator of Microtubule Dynamics Protein 3 (RMDN3) Antibody – Rabbit Polyclonal

FAM82A2: a single-pass membrane protein in the mitochondrial membrane. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. Present at high level in epidermis and seminiferous epithelium: while basal cells in the epidermis and spermatogonia show no perceptible amount, keratinocytes of suprabasal layers and differentiating first-order spermatocytes up to spermatids exhibit high expression. In skeletal muscle, its presence is restricted to fibers of the fast twitch type. In surface epithelia containing ciliated cells, it is associated with the microtubular structures responsible for ciliary movement. Also present in specific structures of the central nervous system such as neurons of the hippocampal region, ganglion cells of the autonomic nervous system, and axons of the peripheral nervous system. Induced by EGF, TGF-beta, retinoic acid-and 1,25-Dihydroxyvitamin D(3). Two alternatively spliced human isoforms may be produced.

Protein type: Membrane protein, integral; Mitochondrial; Apoptosis

Chromosomal Location of Human Ortholog: 15q15.1

Cellular Component: integral to membrane; microtubule; mitochondrial outer membrane; mitochondrion; nucleus; spindle pole

Molecular Function: protein binding

Biological Process: apoptosis; cell differentiation; cellular calcium ion homeostasis