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E3 Ubiquitin-Protein Ligase RNF125 (RNF125) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1497054

E3 ubiquitin-protein ligase that acts as a positive regulator of T-cell activation. E3 ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. More details

$230 / 0.05 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
E3 ubiquitin-protein ligase RNF125, Polyclonal Antibody
Full Product Name
Rabbit anti-human E3 ubiquitin-protein ligase RNF125 polyclonal Antibody(RNF125)
Product Gene Name
Product Synonym Names
RING finger protein 125; T-cell RING activation protein 1; TRAC-1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Molecular Weight
26,454 Da
OMIM
610432
3D Structure
ModBase 3D Structure for Q96EQ8
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human E3 ubiquitin-protein ligase RNF125 protein (1-232aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-85188
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-RNF125 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-RNF125 antibody
Recommended dilution: IHC:1:20-1:200

Immunohistochemistry (IHC) of anti-RNF125 antibody

Immunohistochemistry of paraffin-embedded human skin using MBS1497054 at dilution 1:100
Rabbit Anti-RNF125 Polyclonal Antibody – Cat# MBS1497054

Immunohistochemistry (IHC) of anti-RNF125 antibody

Immunohistochemistry of paraffin-embedded human spleen using MBS1497054 at dilution 1:100
Rabbit Anti-RNF125 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1497054

Other Notes

Small volumes of anti-RNF125 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RNF125 purchase

MBS1497054 is an antibody targeting RNF125. Also known as Rabbit anti-human E3 ubiquitin-protein ligase RNF125 polyclonal Antibody(RNF125). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RNF125. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
E3 ubiquitin-protein ligase RNF125
NCBI Official Synonym Full Names
ring finger protein 125, E3 ubiquitin protein ligase
NCBI Official Symbol
RNF125
NCBI Official Synonym Symbols
TNORS; TRAC1; TRAC-1
UniProt Protein Name
E3 ubiquitin-protein ligase RNF125
UniProt Synonym Protein Names
RING finger protein 125; T-cell RING activation protein 1; TRAC-1
UniProt Gene Name
RNF125
UniProt Synonym Gene Names
TRAC-1
UniProt Entry Name
RN125_HUMAN
NCBI Protein Information
E3 ubiquitin-protein ligase RNF125

NCBI Summary for RNF125

This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway. [provided by RefSeq, Mar 2012]
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UniProt Comments for RNF125

RNF125: E3 ubiquitin-protein ligase that acts as a positive regulator of T-cell activation. E3 ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins.

Protein type: EC 6.3.2.19; EC 6.3.2.-; Ubiquitin ligase; Ligase; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 18q12.1

Cellular Component: intracellular

Molecular Function: ligase activity; ubiquitin conjugating enzyme binding; zinc ion binding

Biological Process: adaptive immune response; innate immune response; negative regulation of interferon type I production; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination

Disease: Tenorio Syndrome
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RNF125 antibody

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