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ATXN7L3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1497106

Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ATXN7L3, Polyclonal Antibody
Full Product Name
ATXN7L3 Antibody
Product Gene Name
anti-ATXN7L3 antibody
Product Synonym Names
Ataxin-7-like protein 3, ATXN7L3; SAGA-associated factor 11 homolog
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Liquid
Purity/Purification
>95%, Protein G Purified
Preparation and Storage
Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Matching Pairs
Unconjugated Antibody: ATXN7L3 (MBS1497106)
HRP Conjugated Antibody: ATXN7L3 (MBS1492076)
Matching Pairs
Unconjugated Antibody: ATXN7L3 (MBS1497106)
Biotin Conjugated Antibody: ATXN7L3 (MBS1494815)
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3D Structure
ModBase 3D Structure for Q14CW9
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
Non-conjugated
Immunogen
Recombinant human Ataxin-7-like protein 3 protein (51-347AA)
Immunogen Species
Homo sapiens (Human)
Research Area
Epigenetics and Nuclear Signaling
Target Names
ATXN7L3
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-241879 / sc-241880
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-ATXN7L3 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-ATXN7L3 antibody
IHC:1:20-1:200

Immunohistochemistry (IHC) of anti-ATXN7L3 antibody

Immunohistochemistry of paraffin-embedded human gastric cancer using MBS1497106 at dilution of 1:100
Rabbit Anti-ATXN7L3 Polyclonal Antibody – Cat# MBS1497106

Other Notes

Small volumes of anti-ATXN7L3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ATXN7L3 purchase

MBS1497106 is an antibody targeting ATXN7L3. Also known as ATXN7L3 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ATXN7L3. It may not necessarily be applicable to this product.

NCBI GI #
149588534
NCBI GeneID
56970
NCBI Accession #
NP_001092303.1
UniProt Primary Accession #
Q14CW9
UniProt Secondary Accession #
Q8IY68; Q96N40; Q9NPU5
UniProt Related Accession #
Q14CW9
GenBank Nucleotide #
NM_001098833.1
NCBI Official Full Name
ataxin-7-like protein 3 isoform b
NCBI Official Synonym Full Names
ataxin 7 like 3
NCBI Official Symbol
ATXN7L3
UniProt Protein Name
Ataxin-7-like protein 3
UniProt Synonym Protein Names
SAGA-associated factor 11 homolog
Protein Family
Ataxin
UniProt Gene Name
ATXN7L3
UniProt Entry Name
AT7L3_HUMAN
NCBI Protein Information
ataxin-7-like protein 3

UniProt Comments for ATXN7L3

ataxin-7L3: Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex. Belongs to the SGF11 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system; Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 17q21.31

Molecular Function: ligand-dependent nuclear receptor transcription coactivator activity; protein binding; transcription coactivator activity; zinc ion binding

Biological Process: establishment and/or maintenance of chromatin architecture; histone deubiquitination; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent
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Research Articles on ATXN7L3

1. Downregulation of ATXN7L3 by short hairpin RNA speci fi cally inactivated the SAGA deubiquitination activity, leading to a strong increase of global H2B ubiquitination and a moderate increase of H2A ubiquitination.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ATXN7L3 antibody

 Reference Product  PubMed Publications
 ENY2 antibody  >4 publications with ATXN7L3 and ENY2
 USP22 antibody  >4 publications with ATXN7L3 and USP22
 ATXN7 antibody  >3 publications with ATXN7L3 and ATXN7

Pathways associated with anti-ATXN7L3 antibody

 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 HATs Acetylate Histones Pathway antibodies  HATs Acetylate Histones Pathway Diagram

Diseases associated with anti-ATXN7L3 antibody

 Disease Name  Pubmed Publications
 Chromosome Aberrations Antibodies  >1 publications with ATXN7L3 and Chromosome Aberrations
 Learning Disorders Antibodies  >1 publications with ATXN7L3 and Learning Disorders
 Neurobehavioral Manifestations Antibodies  >1 publications with ATXN7L3 and Neurobehavioral Manifestations

Organs/Tissues associated with anti-ATXN7L3 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >2 publications with ATXN7L3 and Nerve
 Muscle Antibodies  >1 publications with ATXN7L3 and Muscle
 Heart Antibodies  >1 publications with ATXN7L3 and Heart
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