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PIAS2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1497201

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the… More details

$230 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PIAS2, Polyclonal Antibody
Full Product Name
PIAS2 Antibody, HRP conjugated
Product Gene Name
anti-PIAS2 antibody
Product Synonym Names
E3 SUMO-protein ligase PIAS2; Androgen receptor-interacting protein 3; ARIP3; DAB2-interacting protein; DIP; Msx-interacting zinc finger protein; PIAS-NY protein; Protein inhibitor of activated STAT x; Protein inhibitor of activated STAT2; PIAS2; PIASX
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Caprylic Acid Ammonium Sulfate Precipitation Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Matching Pairs
Unconjugated Antibody: PIAS2 (MBS1491838)
HRP Conjugated Antibody: PIAS2 (MBS1497201)
Molecular Weight
45,057 Da
OMIM
603567
3D Structure
ModBase 3D Structure for O75928
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
HRP
Immunogen
Recombinant human E3 SUMO-protein ligase PIAS2 protrin(1-572AA)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-18245 / sc-30879 / sc-30878
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-PIAS2 antibody
ELISA (EIA)

Other Notes

Small volumes of anti-PIAS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PIAS2 purchase

MBS1497201 is an antibody targeting PIAS2. Also known as PIAS2 Antibody, HRP conjugated. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PIAS2. It may not necessarily be applicable to this product.

NCBI GI #
56699458
NCBI GeneID
9063
NCBI Accession #
NP_004662.2
UniProt Primary Accession #
O75928
UniProt Secondary Accession #
O75927; Q96BT5; Q96KE3
UniProt Related Accession #
O75928
GenBank Nucleotide #
NM_004671.3
NCBI Official Full Name
E3 SUMO-protein ligase PIAS2 isoform beta
NCBI Official Synonym Full Names
protein inhibitor of activated STAT 2
NCBI Official Symbol
PIAS2
NCBI Official Synonym Symbols
DIP; MIZ; MIZ1; SIZ2; ARIP3; PIASX; ZMIZ4; PIASX-BETA; PIASX-ALPHA
UniProt Protein Name
E3 SUMO-protein ligase PIAS2
UniProt Synonym Protein Names
Androgen receptor-interacting protein 3; ARIP3; DAB2-interacting protein; DIP; Msx-interacting zinc finger protein; Miz1; PIAS-NY protein; Protein inhibitor of activated STAT x; Protein inhibitor of activated STAT2
Protein Family
E3 SUMO-protein ligase
UniProt Gene Name
PIAS2
UniProt Synonym Gene Names
PIASX; ARIP3; DIP; Miz1
UniProt Entry Name
PIAS2_HUMAN
NCBI Protein Information
E3 SUMO-protein ligase PIAS2

NCBI Summary for PIAS2

This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2011]
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Research Articles on PIAS2

1. the expression of SENP8, SAE1, PIAS1, PIAS2 and ZMIZ1 is deregulated in the majority of PTC tissues, likely contributing to the PTC phenotype.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PIAS2 antibody

 Reference Product  PubMed Publications
 SUMO1 antibody  >23 publications with PIAS2 and SUMO1
 SUMO2 antibody  >6 publications with PIAS2 and SUMO2
 STAT1 antibody  >4 publications with PIAS2 and STAT1
 MYC antibody  >3 publications with PIAS2 and MYC
 STAT3 antibody  >1 publications with PIAS2 and STAT3
 SMAD4 antibody  >1 publications with PIAS2 and SMAD4
 STAT4 antibody  >1 publications with PIAS2 and STAT4

Pathways associated with anti-PIAS2 antibody

 Products by Pathway  Pathway Diagram
 Activation Of HOX Genes During Differentiation Pathway antibodies  Activation Of HOX Genes During Differentiation Pathway Diagram
 Activation Of Anterior HOX Genes In Hindbrain Development During Early Embryogenesis Pathway antibodies  Activation Of Anterior HOX Genes In Hindbrain Development During Early Embryogenesis Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 IL12 Signaling Mediated By STAT4 Pathway antibodies  IL12 Signaling Mediated By STAT4 Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Pathways In Cancer antibodies  Pathways In Cancer Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 SUMO E3 Ligases SUMOylate Target Proteins Pathway antibodies  SUMO E3 Ligases SUMOylate Target Proteins Pathway Diagram

Diseases associated with anti-PIAS2 antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >3 publications with PIAS2 and Immune System Diseases
 Immunoproliferative Disorders Antibodies  >2 publications with PIAS2 and Immunoproliferative Disorders
 Brain Diseases Antibodies  >1 publications with PIAS2 and Brain Diseases
 Chromosome Aberrations Antibodies  >1 publications with PIAS2 and Chromosome Aberrations
 Congenital Abnormalities Antibodies  >1 publications with PIAS2 and Congenital Abnormalities
 Fibrosis Antibodies  >1 publications with PIAS2 and Fibrosis
 Nerve Degeneration Antibodies  >1 publications with PIAS2 and Nerve Degeneration
 Inflammation Antibodies  >1 publications with PIAS2 and Inflammation

Organs/Tissues associated with anti-PIAS2 antibody

 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >3 publications with PIAS2 and Bone
 Brain Antibodies  >3 publications with PIAS2 and Brain
 Muscle Antibodies  >2 publications with PIAS2 and Muscle
 Thyroid Antibodies  >1 publications with PIAS2 and Thyroid
 Liver Antibodies  >1 publications with PIAS2 and Liver
 Pancreas Antibodies  >1 publications with PIAS2 and Pancreas
 Embryonic Tissue Antibodies  >1 publications with PIAS2 and Embryonic Tissue
 Testis Antibodies  >1 publications with PIAS2 and Testis
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