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Aminoacyl Trna Synthase Complex-Interacting Multifunctional Protein 1 (AIMP1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1497311

Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. Binds tRNA. Possesses inflammatory cytokine activity. Negatively regulates TGF-beta signaling through stabilization of SMURF2 by… More details

$230 / 0.05 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1), Polyclonal Antibody
Full Product Name
Rabbit anti-human Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 polyclonal Antibody(AIMP1)
Product Gene Name
anti-AIMP1 antibody
Product Synonym Names
Multisynthase complex auxiliary component p43; EMAP-2; Endothelial monocyte-activating polypeptide II; EMAP-II; Small inducible cytokine subfamily E member 1; AIMP1; EMAP2; SCYE1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Molecular Weight
37,039 Da
OMIM
260600
3D Structure
ModBase 3D Structure for Q12904
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 protein(25-180aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-27564 / sc-66879
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-AIMP1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
Application Notes for anti-AIMP1 antibody
Recommended dilution: WB:1:500-2000
IHC:1:20-1:200

Western Blot (WB) of anti-AIMP1 antibody

Western blot
All lanes: Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 antibody at 2ug/ml+HepG2 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 35,38 kDa
Observed band size: 34 kDa
Rabbit Anti-AIMP1 Polyclonal Antibody – Cat# MBS1497311

Immunohistochemistry (IHC) of anti-AIMP1 antibody

Immunohistochemistry of paraffin-embedded human cervical cancer using MBS1497311 at dilution 1:100
Rabbit Anti-AIMP1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1497311

Immunohistochemistry (IHC) of anti-AIMP1 antibody

Immunohistochemistry of paraffin-embedded human colon cancer using MBS1497311 at dilution 1:100
Rabbit Anti-AIMP1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1497311

Immunoprecipitation (IP) of anti-AIMP1 antibody

Immunoprecipitating AIMP1 in HepG2 whole cell lysate
Lane 1: Rabbit monoclonal IgG(1ug)instead of MBS1497311 in HepG2 whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000)
Lane 2: MBS1497311(4ug)+ HepG2 whole cell lysate(500ug)
Lane 3: HepG2 whole cell lysate (20ug)
Rabbit Anti-AIMP1 Polyclonal Antibody, Immunoprecipitation (IP) – Cat# MBS1497311

Other Notes

Small volumes of anti-AIMP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AIMP1 purchase

MBS1497311 is an antibody targeting AIMP1. Also known as Rabbit anti-human Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 polyclonal Antibody(AIMP1). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AIMP1. It may not necessarily be applicable to this product.

NCBI GI #
215490009
NCBI GeneID
9255
NCBI Accession #
NP_001135887.1
UniProt Primary Accession #
Q12904
UniProt Secondary Accession #
Q6FG28; Q96CQ9; B3KTR2; B4E1S7
UniProt Related Accession #
Q12904
GenBank Nucleotide #
NM_001142415.1
NCBI Official Full Name
aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform a
NCBI Official Synonym Full Names
aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
NCBI Official Symbol
AIMP1
NCBI Official Synonym Symbols
p43; HLD3; EMAP2; SCYE1; EMAPII
UniProt Protein Name
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
UniProt Synonym Protein Names
Multisynthase complex auxiliary component p43
Protein Family
Aminoacyl tRNA synthase complex-interacting multifunctional protein
UniProt Gene Name
AIMP1
UniProt Synonym Gene Names
EMAP2; SCYE1; EMAP-2; EMAP-II
UniProt Entry Name
AIMP1_HUMAN
NCBI Protein Information
aminoacyl tRNA synthase complex-interacting multifunctional protein 1

NCBI Summary for AIMP1

The protein encoded by this gene is a cytokine that is specifically induced by apoptosis, and it is involved in the control of angiogenesis, inflammation, and wound healing. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor protein is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex, and it modulates aminoacylation activity of tRNA synthetase in normal cells. This protein is also involved in the stimulation of inflammatory responses after proteolytic cleavage in tumor cells. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2008]
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Research Articles on AIMP1

1. AIMP1 appears to function as a novel inhibitor of PPARgamma that regulates adipocyte differentiation by preventing the transcriptional activation of PPARgamma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AIMP1 antibody

 Reference Product  PubMed Publications
 AIMP2 antibody  >9 publications with AIMP1 and AIMP2
 EPRS antibody  >3 publications with AIMP1 and EPRS
 LARS antibody  >2 publications with AIMP1 and LARS
 KARS antibody  >2 publications with AIMP1 and KARS
 RARS antibody  >2 publications with AIMP1 and RARS
 MARS antibody  >2 publications with AIMP1 and MARS
 DARS antibody  >1 publications with AIMP1 and DARS
 IARS antibody  >1 publications with AIMP1 and IARS
 EEF1E1 antibody  >1 publications with AIMP1 and EEF1E1
 QARS antibody  >1 publications with AIMP1 and QARS

Pathways associated with anti-AIMP1 antibody

 Products by Pathway  Pathway Diagram
 Cytosolic TRNA Aminoacylation Pathway antibodies  Cytosolic TRNA Aminoacylation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 SeMet Incorporation Into Proteins Pathway antibodies  SeMet Incorporation Into Proteins Pathway Diagram
 Selenoamino Acid Metabolism Pathway antibodies  Selenoamino Acid Metabolism Pathway Diagram
 TRNA Aminoacylation Pathway antibodies  TRNA Aminoacylation Pathway Diagram

Diseases associated with anti-AIMP1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >9 publications with AIMP1 and Inflammation
 Atrophy Antibodies  >2 publications with AIMP1 and Atrophy
 Fibrosis Antibodies  >2 publications with AIMP1 and Fibrosis
 Liver Diseases Antibodies  >1 publications with AIMP1 and Liver Diseases
 Breast Neoplasms Antibodies  >1 publications with AIMP1 and Breast Neoplasms
 Nervous System Malformations Antibodies  >1 publications with AIMP1 and Nervous System Malformations
 Congenital Abnormalities Antibodies  >1 publications with AIMP1 and Congenital Abnormalities
 Hyperplasia Antibodies  >1 publications with AIMP1 and Hyperplasia

Organs/Tissues associated with anti-AIMP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >15 publications with AIMP1 and Blood
 Lung Antibodies  >4 publications with AIMP1 and Lung
 Bone Antibodies  >4 publications with AIMP1 and Bone
 Stomach Antibodies  >3 publications with AIMP1 and Stomach
 Vascular Antibodies  >3 publications with AIMP1 and Vascular
 Brain Antibodies  >3 publications with AIMP1 and Brain
 Muscle Antibodies  >2 publications with AIMP1 and Muscle
 Liver Antibodies  >2 publications with AIMP1 and Liver
 Intestine Antibodies  >2 publications with AIMP1 and Intestine
 Spleen Antibodies  >2 publications with AIMP1 and Spleen
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