Rabbit Anti-WHSC1L1 Polyclonal Antibody – Cat# MBS1497552

Immunohistochemistry of paraffin-embedded human ovarian cancer using MBS1497552 at dilution of 1:100

WHSC1L1 Antibody – Rabbit Polyclonal

Name: WHSC1L1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS1497552
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1497552

Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. More details

$230 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

WHSC1L1, Polyclonal Antibody

Full Product Name

WHSC1L1 Antibody

Product Gene Name

anti-WHSC1L1 antibody

Product Synonym Names

Histone-lysine N-methyltransferase NSD3 (EC:2.1.1.43); WHSC1L1; NSD3; DC28; Nuclear SET domain-containing protein 3; Protein whistle; WHSC1-like 1 isoform 9 with methyltransferase activity to lysine; Wolf-Hirschhorn syndrome candidate 1-like protein 1; WHSC1-like protein 1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Purity/Purification

>95%, Protein G Purified

Preparation and Storage

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Matching Pairs

Unconjugated Antibody: WHSC1L1 (MBS1497552)
Biotin Conjugated Antibody: WHSC1L1 (MBS1495439)

Matching Pairs

Unconjugated Antibody: WHSC1L1 (MBS1497552)
HRP Conjugated Antibody: WHSC1L1 (MBS1496479)

Molecular Weight

160,314 Da

OMIM

607083

3D Structure

ModBase 3D Structure for Q9BZ95

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Conjugate

Non-conjugated

Immunogen

Recombinant human Histone-lysine N-methyltransferase NSD3 protein

Santa Cruz Alternative

Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-50151 / sc-50152 / sc-50153 / sc-50154 / sc-134817

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-WHSC1L1 antibody

ELISA (EIA), Immunohistochemistry (IHC)

Other Notes

Small volumes of anti-WHSC1L1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for WHSC1L1 purchase

MBS1497552 is an antibody targeting WHSC1L1. Also known as WHSC1L1 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for WHSC1L1. It may not necessarily be applicable to this product.

NCBI GI #

13699813

NCBI GeneID

54904

NCBI Accession #

NP_060248.2

UniProt Primary Accession #

Q9BZ95

UniProt Secondary Accession #

Q1RMD3; Q3B796; Q6ZSA5; Q9BYU8; Q9BYU9; Q9H2M8; Q9H9W9; Q9NXA6; B7ZL11; D3DSX1

UniProt Related Accession #

Q9BZ95

GenBank Nucleotide #

NM_017778.2

NCBI Official Full Name

histone-lysine N-methyltransferase NSD3 isoform short

NCBI Official Synonym Full Names

Wolf-Hirschhorn syndrome candidate 1-like 1

NCBI Official Symbol

WHSC1L1

NCBI Official Synonym Symbols

NSD3; pp14328

UniProt Protein Name

Histone-lysine N-methyltransferase NSD3

UniProt Synonym Protein Names

Nuclear SET domain-containing protein 3; Protein whistle; WHSC1-like 1 isoform 9 with methyltransferase activity to lysine; Wolf-Hirschhorn syndrome candidate 1-like protein 1; WHSC1-like protein 1

Protein Family

Histone-lysine N-methyltransferase

UniProt Gene Name

WHSC1L1

UniProt Synonym Gene Names

NSD3; WHSC1-like protein 1

UniProt Entry Name

NSD3_HUMAN

NCBI Protein Information

histone-lysine N-methyltransferase NSD3

NCBI Summary for WHSC1L1

This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. [provided by RefSeq, May 2015]

UniProt Comments for WHSC1L1

WHSC1L1: is related to the Wolf-Hirschhorn syndrome candidate-1 protein containing PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined. Two alternatively spliced isoforms have been described.

Protein type: Oncoprotein; Histone-binding; EC 2.1.1.43; Amino Acid Metabolism - lysine degradation; Methyltransferase; Methyltransferase, protein lysine

Chromosomal Location of Human Ortholog: 8p11.2

Cellular Component: chromosome; nucleoplasm; nucleus

Molecular Function: histone lysine N-methyltransferase activity (H3-K27 specific); histone lysine N-methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; protein binding; zinc ion binding

Biological Process: establishment and/or maintenance of chromatin architecture; histone H3-K4 methylation; histone methylation; negative regulation of transcription, DNA-dependent; transcription, DNA-dependent

Disease: Leukemia, Acute Myeloid

Research Articles on WHSC1L1

1. The results describe the binding of NSD1, 2 and 3 catalytic domains (CD) on histone tails through recognition of histone-lysine and methylation properties.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-WHSC1L1 antibody

Reference Product	PubMed Publications
KDM1B antibody	>1 publications with WHSC1L1 and KDM1B

Pathways associated with anti-WHSC1L1 antibody

Products by Pathway	Pathway Diagram
Chromatin Modifying Enzymes Pathway antibodies	Chromatin Modifying Enzymes Pathway Diagram
Chromatin Organization Pathway antibodies	Chromatin Organization Pathway Diagram
Lysine Degradation Pathway antibodies	Lysine Degradation Pathway Diagram
Lysine Degradation Pathway antibodies	Lysine Degradation Pathway Diagram
PKMTs Methylate Histone Lysines Pathway antibodies	PKMTs Methylate Histone Lysines Pathway Diagram

Diseases associated with anti-WHSC1L1 antibody

Disease Name	Pubmed Publications
Lung Neoplasms Antibodies	>6 publications with WHSC1L1 and Lung Neoplasms
Chromosome Aberrations Antibodies	>4 publications with WHSC1L1 and Chromosome Aberrations
Leukemia, Myeloid, Acute Antibodies	>3 publications with WHSC1L1 and Leukemia, Myeloid, Acute
Mental Disorders Antibodies	>2 publications with WHSC1L1 and Mental Disorders
Cell Transformation, Neoplastic Antibodies	>2 publications with WHSC1L1 and Cell Transformation, Neoplastic
Death Antibodies	>2 publications with WHSC1L1 and Death
Neoplasm Invasiveness Antibodies	>1 publications with WHSC1L1 and Neoplasm Invasiveness
Neurobehavioral Manifestations Antibodies	>1 publications with WHSC1L1 and Neurobehavioral Manifestations
Liver Neoplasms Antibodies	>1 publications with WHSC1L1 and Liver Neoplasms
Inflammation Antibodies	>1 publications with WHSC1L1 and Inflammation

Organs/Tissues associated with anti-WHSC1L1 antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>8 publications with WHSC1L1 and Lung
Bone Antibodies	>3 publications with WHSC1L1 and Bone
Blood Antibodies	>3 publications with WHSC1L1 and Blood
Bone Marrow Antibodies	>2 publications with WHSC1L1 and Bone Marrow
Prostate Antibodies	>1 publications with WHSC1L1 and Prostate
Muscle Antibodies	>1 publications with WHSC1L1 and Muscle
Liver Antibodies	>1 publications with WHSC1L1 and Liver
Vascular Antibodies	>1 publications with WHSC1L1 and Vascular
Mammary Gland Antibodies	>1 publications with WHSC1L1 and Mammary Gland
Nerve Antibodies	>1 publications with WHSC1L1 and Nerve