Cadherin-13 (CDH13) Antibody – Rabbit Polyclonal

This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]

CDH13: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 16q23.3

Cellular Component: caveola; cytoplasm; external side of plasma membrane; extracellular space; focal adhesion; neuron projection; perinuclear region of cytoplasm; plasma membrane

Molecular Function: adiponectin binding; cadherin binding; calcium ion binding; low-density lipoprotein binding; protein homodimerization activity

Biological Process: calcium-dependent cell-cell adhesion; endothelial cell migration; homophilic cell adhesion; intercellular junction assembly and maintenance; keratinocyte proliferation; lamellipodium biogenesis; localization within membrane; low density lipoprotein mediated signaling; mitotic cell cycle; negative regulation of cell adhesion; negative regulation of cell proliferation; positive regulation of calcium-mediated signaling; positive regulation of cell migration; positive regulation of cell-matrix adhesion; positive regulation of endothelial cell proliferation; positive regulation of positive chemotaxis; positive regulation of smooth muscle cell proliferation; positive regulation of transcription from RNA polymerase II promoter; Rac protein signal transduction; regulation of endocytosis; regulation of epidermal growth factor receptor signaling pathway; Rho protein signal transduction; sprouting angiogenesis