ZC3H12A Antibody – Rabbit Polyclonal

MCPIP1: Has RNase activity and selectively degrades specific target mRNA species. Modulates the immune response and inflammation by regulating the decay of specific mRNA molecules. Recognizes the 3'-untranslated region (UTR) of the mRNA for IL6, CALCR and IL12B. Required for normal decay of IL6 mRNA. Triggers apoptosis and promotes angiogenesis in response to the binding of CCL2 to CCR2. Regulates expression of CDH12 and CHD19. Belongs to the ZC3H12 family.

Protein type: EC 3.1.-.-; Hydrolase

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: cytoplasm; cytoskeleton; nucleoplasm; nucleus; plasma membrane; rough endoplasmic reticulum

Molecular Function: chromatin binding; DNA binding; endoribonuclease activity; exoribonuclease activity; metal ion binding; miRNA binding; mRNA 3'-UTR binding; mRNA binding; protein binding; ribonuclease activity; RNA binding

Biological Process: angiogenesis; apoptosis; cell differentiation; inhibition of NF-kappaB transcription factor; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of interleukin-1 beta secretion; negative regulation of interleukin-6 production; negative regulation of macrophage activation; negative regulation of NF-kappaB import into nucleus; negative regulation of nitric oxide biosynthetic process; negative regulation of tumor necrosis factor production; positive regulation of angiogenesis; positive regulation of autophagy; positive regulation of defense response to virus by host; positive regulation of fat cell differentiation; positive regulation of transcription from RNA polymerase II promoter; protein oligomerization