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KDM8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1498332

Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1… More details

$230 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
KDM8, Polyclonal Antibody
Full Product Name
KDM8 Antibody
Product Gene Name
Product Synonym Names
Lysine-specific demethylase 8 (EC:1.14.11.27); KDM8; JMJD5; JmjC domain-containing protein 5; Jumonji domain-containing protein 5
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
>95%, Protein G Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Matching Pairs
Unconjugated Antibody: KDM8 (MBS1498332)
HRP Conjugated Antibody: KDM8 (MBS1492394)
Matching Pairs
Unconjugated Antibody: KDM8 (MBS1498332)
FITC Conjugated Antibody: KDM8 (MBS1494131)
Molecular Weight
50,852 Da
OMIM
611917
3D Structure
ModBase 3D Structure for Q8N371
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
Non-conjugated
Immunogen
Recombinant human Lysine-specific demethylase 8 protein
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-69428 / sc-69429 / sc-133701
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-KDM8 antibody
ELISA (EIA), Immunohistochemistry (IHC)

Immunohistochemistry (IHC) of anti-KDM8 antibody

Immunohistochemistry of paraffin-embedded human testis tissue using MBS1498332 at dilution of 1:100
Rabbit Anti-KDM8 Polyclonal Antibody – Cat# MBS1498332

Other Notes

Small volumes of anti-KDM8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KDM8 purchase

MBS1498332 is an antibody targeting KDM8. Also known as KDM8 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for KDM8. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
lysine-specific demethylase 8 isoform 1
NCBI Official Synonym Full Names
lysine (K)-specific demethylase 8
NCBI Official Symbol
KDM8
NCBI Official Synonym Symbols
JMJD5
UniProt Protein Name
Lysine-specific demethylase 8
UniProt Synonym Protein Names
JmjC domain-containing protein 5; Jumonji domain-containing protein 5
UniProt Gene Name
KDM8
UniProt Synonym Gene Names
JMJD5
UniProt Entry Name
KDM8_HUMAN
NCBI Protein Information
lysine-specific demethylase 8

NCBI Summary for KDM8

This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009]

UniProt Comments for KDM8

JMJD5: Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Demethylase; EC 1.14.11.27; Cell cycle regulation

Chromosomal Location of Human Ortholog: 16p12.1

Cellular Component: nucleus

Molecular Function: chromatin binding; histone demethylase activity (H3-K36 specific); metal ion binding

Biological Process: G2/M transition of mitotic cell cycle; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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