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Tumor Necrosis Factor Receptor Superfamily Member 27 (EDA2R) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1498483

Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. More details

$230 / 0.05 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Tumor necrosis factor receptor superfamily member 27 (EDA2R), Polyclonal Antibody
Full Product Name
Rabbit anti-human Tumor necrosis factor receptor superfamily member 27 polyclonal Antibody(EDA2R)
Product Gene Name
anti-EDA2R antibody
Product Synonym Names
X-linked ectodysplasin-A2 receptor; EDA-A2 receptor; EDA2R; TNFRSF27; XEDAR
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Molecular Weight
32,959 Da
OMIM
300276
3D Structure
ModBase 3D Structure for Q9HAV5
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Tumor necrosis factor receptor superfamily member 27 protein (1-138aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-15291 / sc-366134
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-EDA2R antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-EDA2R antibody
Recommended dilution: WB:1:500-2000
IHC:1:20-1:200

Western Blot (WB) of anti-EDA2R antibody

All lanes: Tumor necrosis factor receptor superfamily member 27 antibody at 6ug/ml
Lane 1:HepG2 whole cell lysate
Lane 2:Hela whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 33,36 kDa
Observed band size: 33 kDa
Rabbit Anti-EDA2R Polyclonal Antibody – Cat# MBS1498483

Immunohistochemistry (IHC) of anti-EDA2R antibody

Immunohistochemistry of paraffin-embedded human testis using MBS1498483 at dilution 1:100
Rabbit Anti-EDA2R Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1498483

Immunohistochemistry (IHC) of anti-EDA2R antibody

Immunohistochemistry of paraffin-embedded human kidney using MBS1498483 at dilution 1:100
Rabbit Anti-EDA2R Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1498483

Other Notes

Small volumes of anti-EDA2R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EDA2R purchase

MBS1498483 is an antibody targeting EDA2R. Also known as Rabbit anti-human Tumor necrosis factor receptor superfamily member 27 polyclonal Antibody(EDA2R). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for EDA2R. It may not necessarily be applicable to this product.

NCBI GI #
314122209
NCBI GeneID
60401
NCBI Accession #
NP_001186616.1
UniProt Primary Accession #
Q9HAV5
UniProt Secondary Accession #
Q5VYX9; Q5VYY0; Q6UWM2; Q8IZA6
UniProt Related Accession #
Q9HAV5
GenBank Nucleotide #
NM_001199687.2
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 27 isoform 1
NCBI Official Synonym Full Names
ectodysplasin A2 receptor
NCBI Official Symbol
EDA2R
NCBI Official Synonym Symbols
XEDAR; EDAA2R; EDA-A2R; TNFRSF27
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 27
UniProt Synonym Protein Names
X-linked ectodysplasin-A2 receptor; EDA-A2 receptor
Protein Family
Tumor necrosis factor receptor superfamily
UniProt Gene Name
EDA2R
UniProt Synonym Gene Names
TNFRSF27; XEDAR; EDA-A2 receptor
UniProt Entry Name
TNR27_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 27

NCBI Summary for EDA2R

EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that are encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. The protein encoded by this gene specifically binds to EDA-A2 isoform. This protein is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, May 2011]
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UniProt Comments for EDA2R

EDA2R: Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: Xq12

Cellular Component: integral to membrane; integral to plasma membrane; intracellular; plasma membrane

Molecular Function: protein binding; receptor activity; tumor necrosis factor receptor activity

Biological Process: activation of NF-kappaB transcription factor; epidermis development; multicellular organismal development; positive regulation of JNK cascade; tumor necrosis factor-mediated signaling pathway
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Research Articles on EDA2R

1. XEDAR activates the non-canonical NF-kappaB pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-EDA2R antibody

 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 TNFR2 Non-canonical NF-kB Pathway antibodies  TNFR2 Non-canonical NF-kB Pathway Diagram
 TNFs Bind Their Physiological Receptors Pathway antibodies  TNFs Bind Their Physiological Receptors Pathway Diagram

Diseases associated with anti-EDA2R antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >11 publications with EDA2R and Necrosis
 Gastrointestinal Diseases Antibodies  >2 publications with EDA2R and Gastrointestinal Diseases
 Congenital Abnormalities Antibodies  >2 publications with EDA2R and Congenital Abnormalities
 Inflammation Antibodies  >2 publications with EDA2R and Inflammation
 Breast Neoplasms Antibodies  >2 publications with EDA2R and Breast Neoplasms
 Carcinoma Antibodies  >1 publications with EDA2R and Carcinoma
 Ovarian Neoplasms Antibodies  >1 publications with EDA2R and Ovarian Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with EDA2R and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >1 publications with EDA2R and Lung Neoplasms

Organs/Tissues associated with anti-EDA2R antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >7 publications with EDA2R and Skin
 Bone Antibodies  >2 publications with EDA2R and Bone
 Brain Antibodies  >2 publications with EDA2R and Brain
 Muscle Antibodies  >1 publications with EDA2R and Muscle
 Lung Antibodies  >1 publications with EDA2R and Lung
 Embryonic Tissue Antibodies  >1 publications with EDA2R and Embryonic Tissue
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