CHRFAM7A Antibody – Rabbit Polyclonal

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed. [provided by RefSeq, Jul 2008]

CHRFAM7A: Belongs to the ligand-gated ion channel (TC 1.A.9) family

Protein type: Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 15q13.1

Cellular Component: apical plasma membrane; axolemma; external side of plasma membrane; integral to membrane

Molecular Function: extracellular ligand-gated ion channel activity

Biological Process: associative learning; B cell activation; behavioral response to ethanol; behavioral response to nicotine; endocytosis; generation of ovulation cycle rhythm; memory; negative regulation of inflammatory response; negative regulation of interleukin-1 beta production; negative regulation of interleukin-6 production; positive regulation of heart rate in baroreceptor response to decreased systemic arterial blood pressure; regulation of norepinephrine secretion; regulation of synaptic transmission, dopaminergic; response to food; sperm motility; synaptic transmission, cholinergic; T cell activation