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CCL11 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1498799

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3. More details

$230 / 0.05 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CCL11, Polyclonal Antibody
Full Product Name
CCL11 Antibody
Product Gene Name
anti-CCL11 antibody
Product Synonym Names
C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Molecular Weight
10,732 Da
OMIM
601156
3D Structure
ModBase 3D Structure for P51671
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Eotaxin protein (1-97aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-6182 / sc-6181
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CCL11 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CCL11 antibody
Recommended dilution: WB:1:500-2000
IHC:1:20-1:200

Western Blot (WB) of anti-CCL11 antibody

Western blot
All lanes: CCL11 antibody at 5ug/ml+Hela whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 11kDa
Observed band size: 11kDa
Rabbit Anti-CCL11 Polyclonal Antibody – Cat# MBS1498799

Immunohistochemistry (IHC) of anti-CCL11 antibody

Immunohistochemistry of paraffin-embedded human lung tissue using MBS1498799 at dilution 1:100
Rabbit Anti-CCL11 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1498799

Other Notes

Small volumes of anti-CCL11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL11 purchase

MBS1498799 is an antibody targeting CCL11. Also known as CCL11 Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CCL11. It may not necessarily be applicable to this product.

NCBI GI #
4506827
NCBI GeneID
6356
NCBI Accession #
NP_002977.1
UniProt Primary Accession #
P51671
UniProt Secondary Accession #
P50877; Q92490; Q92491
UniProt Related Accession #
P51671
GenBank Nucleotide #
NM_002986.2
NCBI Official Full Name
eotaxin
NCBI Official Synonym Full Names
chemokine (C-C motif) ligand 11
NCBI Official Symbol
CCL11
NCBI Official Synonym Symbols
SCYA11
UniProt Protein Name
Eotaxin
UniProt Synonym Protein Names
C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11
Protein Family
Eotaxin
UniProt Gene Name
CCL11
UniProt Synonym Gene Names
SCYA11
UniProt Entry Name
CCL11_HUMAN
NCBI Protein Information
eotaxin

NCBI Summary for CCL11

This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014]
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UniProt Comments for CCL11

CCL11: In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q12

Cellular Component: extracellular region; extracellular space; intracellular

Molecular Function: CCR chemokine receptor binding; chemokine activity; protein binding

Biological Process: actin filament organization; cell adhesion; cellular calcium ion homeostasis; chemotaxis; chronic inflammatory response; cytoskeleton organization and biogenesis; eosinophil chemotaxis; G-protein coupled receptor protein signaling pathway; inflammatory response; lymphocyte chemotaxis; mast cell chemotaxis; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of actin filament polymerization; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of endothelial cell proliferation; positive regulation of GTPase activity; positive regulation of inflammatory response; protein amino acid phosphorylation; regulation of cell shape; response to radiation; response to virus; signal transduction

Disease: Asthma, Susceptibility To; Human Immunodeficiency Virus Type 1, Susceptibility To
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Research Articles on CCL11

1. High eotaxin and MCP-1 at follow-up was predicted by early disease parameters, and MCP-1 was associated with organ damage at follow-up, highlighting a role of these chemokines in juvenile dermatomyositis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CCL11 antibody

 Reference Product  PubMed Publications
 CCR3 antibody  >339 publications with CCL11 and CCR3
 CCL22 antibody  >62 publications with CCL11 and CCL22
 STAT6 antibody  >62 publications with CCL11 and STAT6
 CCR5 antibody  >62 publications with CCL11 and CCR5
 CCR2 antibody  >50 publications with CCL11 and CCR2
 CXCR3 antibody  >26 publications with CCL11 and CXCR3
 DPP4 antibody  >1 publications with CCL11 and DPP4

Pathways associated with anti-CCL11 antibody

 Products by Pathway  Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 CXCR3-mediated Signaling Events Pathway antibodies  CXCR3-mediated Signaling Events Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram

Diseases associated with anti-CCL11 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >744 publications with CCL11 and Inflammation
 Respiratory Tract Diseases Antibodies  >596 publications with CCL11 and Respiratory Tract Diseases
 Hypersensitivity Antibodies  >582 publications with CCL11 and Hypersensitivity
 Asthma Antibodies  >531 publications with CCL11 and Asthma
 Lung Diseases Antibodies  >488 publications with CCL11 and Lung Diseases
 Respiratory Hypersensitivity Antibodies  >425 publications with CCL11 and Respiratory Hypersensitivity
 Necrosis Antibodies  >203 publications with CCL11 and Necrosis
 Bronchial Hyperreactivity Antibodies  >87 publications with CCL11 and Bronchial Hyperreactivity
 Drug Hypersensitivity Antibodies  >82 publications with CCL11 and Drug Hypersensitivity
 Dermatitis, Atopic Antibodies  >62 publications with CCL11 and Dermatitis, Atopic

Organs/Tissues associated with anti-CCL11 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >508 publications with CCL11 and Lung
 Heart Antibodies  >76 publications with CCL11 and Heart
 Intestine Antibodies  >57 publications with CCL11 and Intestine
 Uterus Antibodies  >14 publications with CCL11 and Uterus
 Kidney Antibodies  >10 publications with CCL11 and Kidney
 Pancreas Antibodies  >7 publications with CCL11 and Pancreas
 Stomach Antibodies  >7 publications with CCL11 and Stomach
 Mammary Gland Antibodies  >3 publications with CCL11 and Mammary Gland
 Uncharacterized Tissue Antibodies  >1 publications with CCL11 and Uncharacterized Tissue
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