ALG5 Antibody – Rabbit Polyclonal

This gene encodes a member of the glycosyltransferase 2 family. The encoded protein participates in glucosylation of the oligomannose core in N-linked glycosylation of proteins. The addition of glucose residues to the oligomannose core is necessary to ensure substrate recognition, and therefore, effectual transfer of the oligomannose core to the nascent glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

ALG5: a member of the glycosyltransferase 2 family. The encoded protein participates in glucosylation of the oligomannose core in N-linked glycosylation of proteins. The addition of glucose residues to the oligomannose core is necessary to ensure substrate recognition, and therefore, effectual transfer of the oligomannose core to the nascent glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

Protein type: Membrane protein, integral; EC 2.4.1.117; Transferase; Glycan Metabolism - N-glycan biosynthesis

Chromosomal Location of Human Ortholog: 13q13.3

Cellular Component: endoplasmic reticulum membrane; integral to membrane; membrane

Molecular Function: dolichyl-phosphate beta-D-mannosyltransferase activity; dolichyl-phosphate beta-glucosyltransferase activity; dolichyl-phosphate-mannose-protein mannosyltransferase activity; oligosaccharyl transferase activity

Biological Process: cellular protein metabolic process; determination of left/right symmetry; dolichol metabolic process; dolichol-linked oligosaccharide biosynthetic process; GPI anchor biosynthetic process; post-translational protein modification; protein amino acid glycosylation; protein amino acid N-linked glycosylation; protein amino acid N-linked glycosylation via asparagine; protein amino acid O-linked mannosylation