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LRRC8E Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1498922

Component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LRRC8E, Polyclonal Antibody
Full Product Name
LRRC8E Antibody
Product Gene Name
anti-LRRC8E antibody
Product Synonym Names
Volume-regulated anion channel subunit LRRC8E; LRRC8E; Leucine-rich repeat-containing protein 8E
Immunogen Sequence
MGDIPDVKND FAFMLHLIDQ YDSLYSKRFA VFLSEVSESR LKQLNLNHEW TPEKLRQKLQ RNAAGRLELA LCMLPGLPDT VFELSEVESL RLEAICDITF PPGLSQLVHL QELSLLHSPA RLPFSLQVFL RDHLKVMRVK CEELREVPLW VFGLRGLEEL HLEGLFPQEL ARAATLESLR ELKQLKVLSL RSNAGKVPAS VTDVAGHLQR LSLHNDGARL VALNSLKKLA ALRELELVAC GLERIPHAVF SLGALQELDL KDNHLRSIEE ILSFQHCR
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
>95%, Protein G Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Matching Pairs
Unconjugated Antibody: LRRC8E (MBS1498922)
HRP Conjugated Antibody: LRRC8E (MBS1496375)
Matching Pairs
Unconjugated Antibody: LRRC8E (MBS1498922)
FITC Conjugated Antibody: LRRC8E (MBS1498605)
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Molecular Weight
90,247 Da
OMIM
612891
3D Structure
ModBase 3D Structure for Q6NSJ5
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
Non-conjugated
Immunogen
Recombinant human volume-regulated anion channel subunit LRRC8E protein, corresponding to amino acids 353-630(Uniprot:Q6NSJ5-1)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-133764
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-LRRC8E antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

Immunohistochemistry (IHC) of anti-LRRC8E antibody

Immunohistochemistry of paraffin-embedded human gastric cancer using MBS1498922 at dilution of 1:100
Rabbit Anti-LRRC8E Polyclonal Antibody – Cat# MBS1498922

Immunohistochemistry (IHC) of anti-LRRC8E antibody

Immunohistochemistry of paraffin-embedded human lung tissue using MBS1498922 at dilution of 1:100
Rabbit Anti-LRRC8E Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1498922

Immunohistochemistry (IHC) of anti-LRRC8E antibody

Immunofluorescent analysis of HepG2 cells using MBS1498922 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Rabbit Anti-LRRC8E Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1498922

Other Notes

Small volumes of anti-LRRC8E antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LRRC8E purchase

MBS1498922 is an antibody targeting LRRC8E. Also known as LRRC8E Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for LRRC8E. It may not necessarily be applicable to this product.

NCBI GI #
392996931
NCBI GeneID
80131
NCBI Accession #
NP_001255213.1
UniProt Primary Accession #
Q6NSJ5
UniProt Secondary Accession #
Q2YDY3; Q7L236; Q8N3B0; Q9H5H8; B3KR78
UniProt Related Accession #
Q6NSJ5
GenBank Nucleotide #
NM_001268284.2
NCBI Official Full Name
volume-regulated anion channel subunit LRRC8E isoform 1
NCBI Official Synonym Full Names
leucine-rich repeat containing 8 family member E
NCBI Official Symbol
LRRC8E
UniProt Protein Name
Volume-regulated anion channel subunit LRRC8E
UniProt Synonym Protein Names
Leucine-rich repeat-containing protein 8E
Protein Family
Volume-regulated anion channel
UniProt Gene Name
LRRC8E
UniProt Entry Name
LRC8E_HUMAN
NCBI Protein Information
volume-regulated anion channel subunit LRRC8E

NCBI Summary for LRRC8E

This gene encodes a member of a small, conserved family of proteins with similar structure, including a string of extracellular leucine-rich repeats. A related protein was shown to be involved in B-cell development. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]
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UniProt Comments for LRRC8E

LRRC8E: Component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8E constitutes a pore-forming subunit or whether it is closely associated with the pore. Belongs to the LRRC8 family. Heterooligomer; heterooligomerizes with other LRRC8 proteins (LRRC8A, LRRC8B, LRRC8C and/or LRRC8D), possibly to form a heterohexamer

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: integral to membrane; plasma membrane

Molecular Function: protein binding

Biological Process: ion transport
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Research Articles on LRRC8E

1. identified four genes, named TA-LRRP, AD158, LRRC5, and FLJ23420, as unknown LRRC8-like genes

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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