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SEMA4C Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1499195

Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By… More details

$230 / 0.05 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SEMA4C, Polyclonal Antibody
Full Product Name
Rabbit anti-human SEMA4C polyclonal Antibody
Product Gene Name
anti-SEMA4C antibody
Product Synonym Names
SEMA4C; KIAA1739; SEMAI
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Antigen Affinity Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Molecular Weight
92,623 Da
OMIM
604462
3D Structure
ModBase 3D Structure for Q9C0C4
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Conjugate
Non-conjugated
Immunogen
Recombinant human Semaphorin-4C protein (749-833aa)
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-169282 / sc-169284
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-SEMA4C antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes for anti-SEMA4C antibody
Recommended dilution: IHC:1:20-1:200

Immunohistochemistry (IHC) of anti-SEMA4C antibody

Immunohistochemistry of paraffin-embedded human tonsil using MBS1499195 at dilution 1:100
Rabbit Anti-SEMA4C Polyclonal Antibody – Cat# MBS1499195

Immunohistochemistry (IHC) of anti-SEMA4C antibody

Immunohistochemistry of paraffin-embedded human brain using MBS1499195 at dilution 1:100
Rabbit Anti-SEMA4C Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS1499195

Other Notes

Small volumes of anti-SEMA4C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SEMA4C purchase

MBS1499195 is an antibody targeting SEMA4C. Also known as Rabbit anti-human SEMA4C polyclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SEMA4C. It may not necessarily be applicable to this product.

NCBI GI #
157388902
NCBI GeneID
54910
NCBI Accession #
NP_060259.4
UniProt Primary Accession #
Q9C0C4
UniProt Secondary Accession #
Q32MJ3; Q7Z5X0
UniProt Related Accession #
Q9C0C4
GenBank Nucleotide #
NM_017789.4
NCBI Official Full Name
semaphorin-4C
NCBI Official Synonym Full Names
semaphorin 4C
NCBI Official Symbol
SEMA4C
NCBI Official Synonym Symbols
SEMAF; SEMAI; SEMACL1; M-SEMA-F
UniProt Protein Name
Semaphorin-4C
Protein Family
Semaphorin
UniProt Gene Name
SEMA4C
UniProt Synonym Gene Names
KIAA1739; SEMAI
UniProt Entry Name
SEM4C_HUMAN
NCBI Protein Information
semaphorin-4C

UniProt Comments for SEMA4C

SEMA4C: Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration. Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade. Belongs to the semaphorin family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q11.2

Cellular Component: cell junction; extracellular space; integral to membrane; membrane; postsynaptic density; postsynaptic membrane; synaptic vesicle membrane

Molecular Function: chemorepellent activity; protein binding; semaphorin receptor binding

Biological Process: cell migration in hindbrain; cerebellum development; muscle cell differentiation; negative chemotaxis; negative regulation of axon extension involved in axon guidance; neural crest cell migration; neural tube closure; positive regulation of cell migration; positive regulation of stress-activated MAPK cascade
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Research Articles on SEMA4C

1. Data suggest that Erbin can interact with Sema4C, and co-expression of Erbin blocks the process of Sema4C-induced epithelial-mesenchymal transition.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SEMA4C antibody

 Reference Product  PubMed Publications
 PLXNB1 antibody  >3 publications with SEMA4C and PLXNB1
 ERBB2IP antibody  >1 publications with SEMA4C and ERBB2IP
 PLXNB2 antibody  >1 publications with SEMA4C and PLXNB2

Pathways associated with anti-SEMA4C antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram

Diseases associated with anti-SEMA4C antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >2 publications with SEMA4C and Brain Diseases
 Fibrosis Antibodies  >2 publications with SEMA4C and Fibrosis
 Liver Diseases Antibodies  >1 publications with SEMA4C and Liver Diseases
 Vascular Diseases Antibodies  >1 publications with SEMA4C and Vascular Diseases
 Disease Models, Animal Antibodies  >1 publications with SEMA4C and Disease Models, Animal
 Fatty Liver Antibodies  >1 publications with SEMA4C and Fatty Liver
 Kidney Diseases Antibodies  >1 publications with SEMA4C and Kidney Diseases
 Inflammation Antibodies  >1 publications with SEMA4C and Inflammation

Organs/Tissues associated with anti-SEMA4C antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >11 publications with SEMA4C and Nerve
 Brain Antibodies  >8 publications with SEMA4C and Brain
 Kidney Antibodies  >4 publications with SEMA4C and Kidney
 Lung Antibodies  >4 publications with SEMA4C and Lung
 Embryonic Tissue Antibodies  >4 publications with SEMA4C and Embryonic Tissue
 Muscle Antibodies  >2 publications with SEMA4C and Muscle
 Skin Antibodies  >2 publications with SEMA4C and Skin
 Liver Antibodies  >1 publications with SEMA4C and Liver
 Blood Antibodies  >1 publications with SEMA4C and Blood
 Stomach Antibodies  >1 publications with SEMA4C and Stomach
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