Rabbit Anti-MIA40 Polyclonal Antibody – Cat# MBS1499231

Mitochondrial Intermembrane Space Import and Assembly Protein 40 (MIA40) Antibody – Rabbit Polyclonal

Name: MIA40 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS1499231
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1499231

Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor… More details

$230 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Mitochondrial intermembrane space import and assembly protein 40 (MIA40), Polyclonal Antibody

Full Product Name

Rabbit anti-human Mitochondrial intermembrane space import and assembly protein 40 polyclonal Antibody, Biotin conjugated

Product Gene Name

anti-MIA40 antibody

Product Synonym Names

Coiled-coil-helix-coiled-coil-helix domain-containing protein 4; CHCHD4

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Purity/Purification

Caprylic Acid Ammonium Sulfate Precipitation Purified

Preparation and Storage

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Matching Pairs

Unconjugated Antibody: MIA40 (MBS1493063)
Biotin Conjugated Antibody: MIA40 (MBS1499231)

Molecular Weight

17,385 Da

OMIM

611077

3D Structure

ModBase 3D Structure for Q8N4Q1

Storage Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Conjugate

Biotin

Immunogen

Recombinant human Mitochondrial intermembrane space import and assembly protein 40 protein(1-142aa)

Santa Cruz Alternative

Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-98628 / sc-102436 / sc-102437

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Applications Tested/Suitable for anti-MIA40 antibody

ELISA (EIA)

Other Notes

Small volumes of anti-MIA40 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MIA40 purchase

MBS1499231 is an antibody targeting MIA40. Also known as Rabbit anti-human Mitochondrial intermembrane space import and assembly protein 40 polyclonal Antibody, Biotin conjugated. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MIA40. It may not necessarily be applicable to this product.

NCBI GI #

148612859

NCBI GeneID

131474

NCBI Accession #

NP_001091972.1

UniProt Primary Accession #

Q8N4Q1

UniProt Secondary Accession #

Q96AI2; Q96MY6; A8K3Z9

UniProt Related Accession #

Q8N4Q1

GenBank Nucleotide #

NM_001098502.1

NCBI Official Full Name

mitochondrial intermembrane space import and assembly protein 40 isoform 1

NCBI Official Synonym Full Names

coiled-coil-helix-coiled-coil-helix domain containing 4

NCBI Official Symbol

CHCHD4

NCBI Official Synonym Symbols

MIA40; TIMM40

UniProt Protein Name

Mitochondrial intermembrane space import and assembly protein 40

UniProt Synonym Protein Names

Coiled-coil-helix-coiled-coil-helix domain-containing protein 4

Protein Family

Mitochondrial intermembrane space import and assembly protein

UniProt Gene Name

CHCHD4

UniProt Synonym Gene Names

MIA40

UniProt Entry Name

MIA40_HUMAN

NCBI Protein Information

mitochondrial intermembrane space import and assembly protein 40

NCBI Summary for MIA40

CHCHD4, a component of human mitochondria, belongs to a protein family whose members share 6 highly conserved cysteine residues constituting a -CXC-CX(9)C-CX(9)C- motif in the C terminus (Hofmann et al., 2005 [PubMed 16185709]).[supplied by OMIM, Mar 2008]

UniProt Comments for MIA40

CHCHD4: Required for the import and folding of small cysteine- containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Probably acts by forming a redox cycle with GFER/ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (Probable). 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial

Chromosomal Location of Human Ortholog: 3p25.1

Cellular Component: mitochondrial intermembrane space; mitochondrion

Molecular Function: protein disulfide oxidoreductase activity

Biological Process: 'de novo' posttranslational protein folding; cellular protein metabolic process; mitochondrial DNA repair; protein import into mitochondrial intermembrane space; protein maturation via protein folding; protein targeting to mitochondrion; regulation of protein export from nucleus

Research Articles on MIA40

1. results demonstrate an indispensable role for hMIA40 for the export of Fe-S clusters from mitochondria.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-MIA40 antibody

Products by Pathway	Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Mitochondrial Protein Import Pathway antibodies	Mitochondrial Protein Import Pathway Diagram

Organs/Tissues associated with anti-MIA40 antibody

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>1 publications with MIA40 and Skin
Brain Antibodies	>1 publications with MIA40 and Brain
Lung Antibodies	>1 publications with MIA40 and Lung