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MED18 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1499336

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase… More details

$230 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MED18, Polyclonal Antibody
Full Product Name
MED18 Antibody, FITC conjugated
Product Gene Name
anti-MED18 antibody
Product Synonym Names
Mediator of RNA polymerase II transcription subunit 18; MED18; Mediator complex subunit 18; p28b
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
>95%, Protein G Purified
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
Matching Pairs
Unconjugated Antibody: MED18 (MBS7005983)
FITC Conjugated Antibody: MED18 (MBS1499336)
Molecular Weight
23,663 Da
OMIM
612384
3D Structure
ModBase 3D Structure for Q9BUE0
Storage Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Conjugate
FITC
Immunogen
Recombinant human Mediator of RNA polymerase II transcription subunit 18 protein
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-161835
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-MED18 antibody
ELISA (EIA)

Other Notes

Small volumes of anti-MED18 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MED18 purchase

MBS1499336 is an antibody targeting MED18. Also known as MED18 Antibody, FITC conjugated. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MED18. It may not necessarily be applicable to this product.

NCBI GI #
188035867
NCBI GeneID
54797
NCBI Accession #
NP_001120822.1
UniProt Primary Accession #
Q9BUE0
UniProt Secondary Accession #
Q9NXU9; D3DPM1
UniProt Related Accession #
Q9BUE0
GenBank Nucleotide #
NM_001127350.1
NCBI Official Full Name
mediator of RNA polymerase II transcription subunit 18
NCBI Official Synonym Full Names
mediator complex subunit 18
NCBI Official Symbol
MED18
NCBI Official Synonym Symbols
p28b
UniProt Protein Name
Mediator of RNA polymerase II transcription subunit 18
UniProt Synonym Protein Names
Mediator complex subunit 18; p28b
Protein Family
Mediator of RNA polymerase II transcription
UniProt Gene Name
MED18
UniProt Entry Name
MED18_HUMAN
NCBI Protein Information
mediator of RNA polymerase II transcription subunit 18

NCBI Summary for MED18

MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]

UniProt Comments for MED18

MED18: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 18 family.

Protein type: Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 1p35.3

Cellular Component: Srb-mediator complex

Molecular Function: protein binding

Biological Process: regulation of transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription
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Research Articles on MED18

1. A novel transcriptional repression mechanism of hMED18 mediated by hCDK8 and further a novel positive role of free CDK/cyclin module in transcriptional activation is described.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MED18 antibody

 Reference Product  PubMed Publications
 MED20 antibody  >9 publications with MED18 and MED20
 MED8 antibody  >8 publications with MED18 and MED8
 MED21 antibody  >1 publications with MED18 and MED21

Pathways associated with anti-MED18 antibody

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 Transcriptional Regulation Of White Adipocyte Differentiation Pathway antibodies  Transcriptional Regulation Of White Adipocyte Differentiation Pathway Diagram

Diseases associated with anti-MED18 antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >1 publications with MED18 and Brain Diseases
 Atherosclerosis Antibodies  >1 publications with MED18 and Atherosclerosis
 Hypertension Antibodies  >1 publications with MED18 and Hypertension
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